Tag results:
myeloid cells
Human Immunology News
Severity of Thermal Burn Injury Is Associated with Systemic Neutrophil Activation
[Scientific Reports] Leukocyte, platelet, neutrophil, and lymphocyte counts were assessed. Scientists analyzed the association of neutrophil-derived factors with clinical severity scoring systems.
Dermal Cell News
TIM-3 Shuttled by MV3 Cells-Secreted Exosomes Inhibits CD4+ T Cell Immune Function and Induces Macrophage M2 Polarization to Promote the Growth and Metastasis of...
[Translational Oncology] Silencing of TIM-3 shuttled by MV3 cells-derived exosomes improved CD4+ T cell immune function and inhibited macrophage M2 polarization to attenuate the growth and metastasis of melanoma cells.
Extracellular Matrix News
Mesenchymal Stromal Cell-Derived Septoclasts Resorb Cartilage during Developmental Ossification and Fracture Healing
[Nature Communications] Scientists showed that matrix degradation and chondrocyte phagocytosis were mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which had a mesenchymal origin and were not derived from hematopoietic cells.
Pulmonary Cell News
Characterizing Cellular Heterogeneity in Fibrotic Hypersensitivity Pneumonitis by Single-Cell Transcriptional Analysis
[Cell Death Discovery] Utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis of fibrotic hypersensitivity pneumonitis profiles, the authors identified ten major cell types and 19 unique subtypes.
Extracellular Matrix News
Tumor-Associated Neutrophils Secrete AGR2 to Promote Colorectal Cancer Metastasis via Its Receptor CD98hc–xCT
[Gut] Scientists investigated the cellular source for secreted anterior gradient-2 (AGR2) in the tumor microenvironment and underlying mechanisms mediating secreted AGR2’s effects.
Hepatic Cell News
Integrative Bioinformatics and Experimental Analysis Revealed TEAD as Novel Prognostic Target for Hepatocellular Carcinoma and Its Roles in Ferroptosis Regulation
[Aging] Investigators indicated that TEAD2/4 were significantly upregulated in HCC compared with normal tissues. Downregulation of TEAD2 promoted the death of HCC cells through inducing ferroptosis by iron accumulation and subsequent oxidative damage.