myeloid cells

[Proceedings of the National Academy of Sciences of the United States of America] Researchers reported that absence of isthmin 1 (ISM1) in mice led to increase in both alveolar macrophages number and functional heterogeneity, with enduring lung inflammation, progressive emphysema, and significant lung function decline, phenotypes similar to human obstructive pulmonary disease.

[Nature Communications] The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.

[Advanced Materials] IFN-γ treatment induced remarkable PD-L1 expression on PD-L1-expressing macrophage membrane (PRM), thereby allowing PRM nanodecoys to bind mPD-1 on CD4+ T cell surfaces or neutralize free sPD-1, which reconstructed the PD-1/PD-L1 inhibitory axis to suppress CD4+ T cell activation and restore immune tolerance.

[American Journal of Respiratory and Critical Care Medicine] The healthy human neutrophil secretome generated under normoxic or hypoxic conditions was characterized by quantitative mass spectrometry, and the capacity for neutrophil-mediated endothelial damage assessed.

[FASEB Journal] Using single-cell RNA-seq, scientists identified macrophages as a source of matrix metalloproteinase 14 in muscle following a hypertrophic exercise stimulus in mice.

[Acta Pharmacologica Sinica] The authors summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.