myeloid cells

[Haematologica] The authors investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be involved in platelet α-granule biogenesis by undertaking transcriptome analysis of control platelets and platelets harboring a DNA-binding variant of FLI1.

[Stem Cell Reports] Investigators studied human iPSCs that had been expanded into a self-formed ectodermal autonomous multi-zone of cells that partially mimicked human eye development.

[NPJ Regenerative Medicine] Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.

[Acta Pharmacologica Sinica] Scientists investigated whether sapidolide A exerted protective effects on macrophages, thus alleviating the secondary hepatocyte damage in an acetaminophen-induced liver injury.

[Journal of Clinical Investigation] Scientists explored the underlying biology in myeloid cells from healthy volunteers following in vivo placebo or nicotinamide riboside administration and subsequently tested the findings in vitro in monocytes extracted from subjects with systemic lupus erythematosus.

[Journal of Clinical Investigation] Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.