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myeloid cells
Immune Regulation News
Disruption of USP9X in Macrophages Promotes Foam Cell Formation and Atherosclerosis
[Journal of Clinical Investigation] Using a loss-of-function lipid accumulation screening, scientists identified ubiquitin-specific peptidase 9 X-linked (USP9X) as a factor that suppressed lipid uptake in macrophages.
Human Immunology News
Single-Cell RNA-Seq Reveals Cell Type-Specific Molecular and Genetic Associations to Lupus
[Science] Researchers demonstrated mux-seq as a systematic approach to characterize cellular composition, identify transcriptional signatures, and annotate genetic variants associated with systemic lupus erythematosus.
Cell Therapy News
Injectable Adhesive Hemostatic Gel with Tumor Acidity Neutralizer and Neutrophil Extracellular Traps Lyase for Enhancing Adoptive NK Cell Therapy Prevents Post-Resection Recurrence of Hepatocellular...
[Biomaterials] A dual pH-responsive hydrogel with tumor acidity neutralizer and neutrophil extracellular traps lyase was developed and used in combination with natural killer cell infusion for preventing post-resection hepatocellular carcinom recurrence.
Mammary Cell News
Modification of BRCA1-Associated Breast Cancer Risk by HMMR Overexpression
[Nature Communications] Researchers depicted an interplay of molecular, cellular, and tissue microenvironment alterations that increased BRCA1-associated breast cancer risk.
Pulmonary Cell News
Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury
[Journal of innate Immunity] Extracellular vesicles released during acute lung injury originated from alveolar epithelial cells, macrophages, and neutrophils and carry a diverse array of lipid mediators derived from ω-3 and ω-6 polyunsaturated fatty acids.
Immunology of Infectious Disease News
mRNA-1273 and BNT162b2 COVID-19 Vaccines Elicit Antibodies with Differences in FC-Mediated Effector Functions
[Science Translational Medicine] Given our emerging appreciation for the importance of additional antibody functions beyond neutralization, we profiled the post-boost binding and functional capacity of humoral immune responses induced by the BNT162b2 and mRNA-1273 vaccines in a cohort of hospital staff.