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myeloid cells

Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate

[Tissue Engineering and Regenerative Medicine] Researchers reported a novel strategy to generate highly pure mouse bone marrow MSCs using liposomal clodronate.

Osteoblast/Osteoclast and Immune Cocktail Therapy of an Exosome/Drug Delivery Multifunctional Hydrogel Accelerates Fracture Repair

[ACS Nano] The authors constructed a cocktail therapy to simultaneously regulate the osteoblast/osteoclast and M1/M2 macrophage balance.

Heterocellular OSM-OSMR Signaling Reprograms Fibroblasts to Promote Pancreatic Cancer Growth and Metastasis

[Nature Communications] Scientists described how heterocellular Oncostatin M (OSM) - Oncostatin M Receptor (OSMR) signaling reprograms fibroblasts, regulates tumor growth and metastasis.

Meteorin-Like Facilitates Skeletal Muscle Repair through a Stat3/IGF-1 Mechanism

[Nature Metabolism] Researchers identified the myokine/cytokine Meteorin-like (Metrnl) as a critical regulator of muscle regeneration.

DRAM1 Increases the Secretion of PKM2-Enriched Extracellular Vesicles from Hepatocytes to Promote Macrophage Activation and Disease Progression in Alcohol-Related Liver Disease

[Molecular Therapy-Nucleic Acids] The authors explored the expression, role and mechanism of DNA damage regulated autophagy modulator 1 (DRAM1) in alcohol-related liver disease and revealed that ethanol-induced DRAM1 of hepatic cells could increase the pyruvate kinase M2 (PKM2)-enriched extracellular vesicles.

Impact of Reactive Iron in Coal Mine Dust on Oxidant Generation and Epithelial Lung Cell Viability

[Science of the Total Environment] Scientists revealed that reduced iron minerals were widely distributed within samples obtained from Australian coal mines with pyrite and siderite being particularly abundant. Compared with carbon and crystalline silica, the presence of these specific iron minerals were negatively correlated to the viability of both alveolar macrophages and human lung epithelial cells.

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