myeloid cells

[mBio] Investigators hypothesized that CCL22 induction was driven by a specific Toxoplasma gondii-secreted effector.

[Stem Cells Translational Medicine] In this review, the gap between the many basic studies and limited clinical trials on stem cell-derived RBCs and platelets is summarized.

[Denali Therapeutics, Inc.] Denali Therapeutics, Inc. announced that its strategic partner Takeda Pharmaceutical Company Limited has exercised an option to co-develop and co-commercialize DNL593, an investigational, brain-penetrant progranulin replacement therapy for the potential treatment of frontotemporal dementia-granulin.

[Nature Communications] Tamoxifen-inducible and microglia-specific depletion of polyglutamine binding protein 1 (PQBP1) in primary culture in vitro and mouse brain in vivo showed that PQBP1 was essential for sensing-tau to induce nuclear translocation of nuclear factor κB (NFκB).

[Cell Death & Disease] To identify key immune players in the tumor microenvironment, investigators applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human monocyte THP-1 cells and identified CXCL7 by cytokine array as one of the increasingly secreted cytokines by THP-1 cells.

[Nature Medicine] Using single-cell RNA sequencing and plasma proteomics, scientists discovered that, compared to bacterial acute respiratory distress syndrom, COVID-19 was associated with the expansion of distinct neutrophil states characterized by interferon and prostaglandin signaling.