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myeloid cells

COMMD10 Is Critical for Kupffer Cell Survival and Controls Ly6Chi Monocyte Differentiation and Inflammation in the Injured Liver

[Cell Reports] Copper metabolism MURR1 domain (COMMD10) deficiency in Kupffer cells and in other tissue-resident macrophages impedes their homeostatic survival, leading to their continuous replacement by Ly6Chi monocytes.

Cancer-Associated MSC Drive Tumor Immune Exclusion and Resistance to Immunotherapy, Which Can Be Overcome by Hedgehog Inhibition

[Science Advances] Using an immune “hot” mouse ovarian cancer model, scientists found that cancer-associated-MSCs drove CD8+ T cell tumor immune exclusion and reduced response to anti–PD-L1 immune checkpoint inhibitor via secretion of numerous chemokines.

TM4SF5-Dependent Crosstalk between Hepatocytes and Macrophages to Reprogram the Inflammatory Environment

[Cell Reports] Scientists investigated the role of TM4SF5 in communication between hepatocytes and macrophages and its possible influence on the inflammatory microenvironment that may lead to nonalcoholic fatty liver disease.

Myelodysplastic/Myeloproliferative Neoplasms-Unclassifiable with Isolated Isochromosome 17q Represents a Distinct Clinico-Biologic Subset: A Multi-Institutional Collaborative Study from the Bone Marrow Pathology Group

[Modern Pathology] Classification of myeloid neoplasms with isolated isochromosome i(17q) is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. Researchers undertook a multi-institutional retrospective study of 92 adult MDS/MPN-U cases from eight institutions.

Acute Myeloid Leukemia Maturation Lineage Influences Residual Disease and Relapse Following Differentiation Therapy

[Nature Communications] Researchers indicated that relapse can originate from therapy-resistant mature acute myeloid leukemia cells, and suggested differentiation therapy combined with targeted eradication of mature leukemia-derived lineages may improve disease outcome.

Signal-Transducing Adaptor Protein-1 and -2 in Hematopoiesis and Diseases

[Experimental Hematology] Recent findings have shown the critical roles of signal-transducing adaptor protein (STAP)-2 in B cell progenitor cells in marrow under hematopoietic stress and STAP-1 and -2 in BCR-ABL-transduced leukemogenesis. In this review, the authors focus on the role of STAPs in the bone marrow.

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