Tag results:
myeloid cells
Hepatic Cell News
COMMD10 Is Critical for Kupffer Cell Survival and Controls Ly6Chi Monocyte Differentiation and Inflammation in the Injured Liver
[Cell Reports] Copper metabolism MURR1 domain (COMMD10) deficiency in Kupffer cells and in other tissue-resident macrophages impedes their homeostatic survival, leading to their continuous replacement by Ly6Chi monocytes.
Mesenchymal Cell News
Cancer-Associated MSC Drive Tumor Immune Exclusion and Resistance to Immunotherapy, Which Can Be Overcome by Hedgehog Inhibition
[Science Advances] Using an immune “hot” mouse ovarian cancer model, scientists found that cancer-associated-MSCs drove CD8+ T cell tumor immune exclusion and reduced response to anti–PD-L1 immune checkpoint inhibitor via secretion of numerous chemokines.
Hepatic Cell News
TM4SF5-Dependent Crosstalk between Hepatocytes and Macrophages to Reprogram the Inflammatory Environment
[Cell Reports] Scientists investigated the role of TM4SF5 in communication between hepatocytes and macrophages and its possible influence on the inflammatory microenvironment that may lead to nonalcoholic fatty liver disease.
Hematopoiesis News
Myelodysplastic/Myeloproliferative Neoplasms-Unclassifiable with Isolated Isochromosome 17q Represents a Distinct Clinico-Biologic Subset: A Multi-Institutional Collaborative Study from the Bone Marrow Pathology Group
[Modern Pathology] Classification of myeloid neoplasms with isolated isochromosome i(17q) is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. Researchers undertook a multi-institutional retrospective study of 92 adult MDS/MPN-U cases from eight institutions.
Hematopoiesis News
Acute Myeloid Leukemia Maturation Lineage Influences Residual Disease and Relapse Following Differentiation Therapy
[Nature Communications] Researchers indicated that relapse can originate from therapy-resistant mature acute myeloid leukemia cells, and suggested differentiation therapy combined with targeted eradication of mature leukemia-derived lineages may improve disease outcome.
Hematopoiesis News
Signal-Transducing Adaptor Protein-1 and -2 in Hematopoiesis and Diseases
[Experimental Hematology] Recent findings have shown the critical roles of signal-transducing adaptor protein (STAP)-2 in B cell progenitor cells in marrow under hematopoietic stress and STAP-1 and -2 in BCR-ABL-transduced leukemogenesis. In this review, the authors focus on the role of STAPs in the bone marrow.