myeloid cells

[Proceedings of the National Academy of Sciences of the United States of America] Researchers reported that desmosterol, the most abundant cholesterol biosynthetic intermediate in human coronary artery lesions, played an essential role during atherogenesis, serving as a key molecule integrating cholesterol homeostasis and immune responses in macrophages.

[Journal of Immunology] Scientists described an immunomodulatory role for an aromatic keto acid, indole-3-pyruvate (I3P). They demonstrated that I3P inhibited the production of PGs in activated macrophages.

[Current Opinion in Immunology] The authors discuss how newly described decidual innate lymphoid cells and maternal placenta-associated macrophage subsets may be involved in anti-pathogen defense.

[Molecular Therapy-Oncolytics] Scientists found that oncolytic adenovirus conferred an effective ability to reduce ascites development and prolong overall survival.

[Science Advances] Investigators reported that interleukin-4 –induced M0 → M2 macrophage polarization was accompanied by interchangeable glucose- or lactate-dependent tricarboxylic acid cycle metabolism that directly drove histone acetylation, M2 gene transcription, and functional immune suppression.

[Journal of Physiology] Researchers defined the nature of microvascular damage and time course of repair during muscle injury and regeneration induced by the myotoxin BaCl2.