myeloid cells

[iScience] Inhibition of matrix metalloprotease 2 (MMP2) restricted functional transfer of hepatic miRNAs across the hepatic and non-hepatic cell boundaries and by targeting MMP2, scientists could reduce the innate immune response in mammalian liver by preventing intra-tissue miR-122 transfer.

[Cell Death Discovery] Investigators isolated radiation-induced senescent tdTOMp16 positive MSCs, established their absence of cell division, then measured levels of irradiation-induced expression of biomarkers of senescence by RNA-seq analysis.

[Laboratory Investigation] MSCs were genetically modified to overexpress placental growth factor, and its effects on macrophage proliferation and polarization were analyzed in vitro in a transwell co-culture system, as well as in vivo in a mouse model for spinal fusion, for which the cells were bilaterally injected into paravertebral muscles of the mouse lumbar spine.

[Nature Communications] Deletion of the apoptotic effectors BAK and BAX prevented MSC death and attenuated their immunosuppressive effects in disease models used to define MSC potency.

[Scientific Reports] Scientists utilized cromolyn, a mast cell inhibitor with anti-inflammatory capabilities, and its fluorinated analogue F-cromolyn to study fibrosis-related protein regulation and secretion downstream of neuroinflammation and their ability to promote microglial phagocytosis and neurite outgrowth.

[Oncogene] Researchers showed that the activation of the RON receptor tyrosine kinase signaling pathway specifically in macrophages supports breast cancer growth and metastasis.