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myocardial infarction

Small Extracellular Vesicles from Menstrual Blood-Derived Mesenchymal Stem Cells (MenSCs) as a Novel Therapeutic Impetus in Regenerative Medicine

[Stem Cell Research & Therapy] The authors describe the basic characteristics and biological functions of menstrual blood-derived MSCs-derived small extracellular vesicles.

Gastrin Mediates Cardioprotection through Angiogenesis after Myocardial Infarction by Activating the HIF-1α/VEGF Signaling Pathway

[Scientific Reports] Researchers hypothesized that gastrin might protect against heart injury after myocardial infarction by promoting angiogenesis. Downregulation of HIF-1α expression by siRNA reduced the proliferation, migration and tube formation of human umbilical vein endothelial cells.

Nrf2 for Cardiac Protection: Pharmacological Options against Oxidative Stress

[Trends in Pharmacological Sciences] Myocardial ischemia or reperfusion increases the generation of reactive oxygen species from damaged mitochondria, NADPH oxidases, xanthine oxidase, and inflammation.

Senescent Cells Suppress Innate Smooth Muscle Cell Repair Functions in Atherosclerosis

[Nature Aging] The authors found that senescent cells inhibited vascular smooth muscle cells (VSMCs) promigratory phenotype switching in the first interfiber space of the arterial wall directly beneath the atherosclerotic plaque, thereby limiting lesion entry of medial VSMCs for fibrous cap assembly or reinforcement.

Complement Dysregulation Is Associated with Severe COVID-19 Illness

[Haematologica] Researchers demonstrated that serum from 58 COVID-19 patients could induce complement-mediated cell death in a functional assay and increase membrane attack complex deposition on the cell surface.

Clonal Hematopoiesis of Indeterminate Potential (CHIP): Linking Somatic Mutations, Hematopoiesis, Chronic Inflammation and Cardiovascular Disease

[Journal of Molecular and Cellular Cardiology] Investigators summarize emerging research on CHIP, the mechanisms underlying its important role in propagating inflammation and accelerating cardiovascular disease, and new studies detailing the role of associated risk factors and co-morbidities that increase CHIP prevalence.

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