myocardial ischemia-reperfusion

[Communications Biology] Researchers showed that KDM3A was significantly downregulated in rat ischemia/reperfusion and cellular hypoxia/reoxygenation models. KDM3A knockout exacerbated cardiac dysfunction and cardiomyocytes injury both in vivo and in vitro.

[Molecular and Cellular Biochemistry] Scientists showed that cardiac fibroblasts protected cardiomyocytes against myocardial ischemia/reperfusion-induced injury through suppression of pyroptosis.

[Cell Death & Disease] After myocardial ischemia reperfusion surgery, IL-1R2 expression was significantly increased in heart of wild-type mice.

[Laboratory Investigation] Researchers revealed that hypoxia/reoxygenation (H/R) treated human cardiac myocytes showed a significantly decreased miR-185-5p expression and increased expression of CDK6 and ROR.

[Histology and Histopathology] Researchers reported that TUG1 expression was induced in mouse heart following myocardial ischemia/reperfusion injury as well as in cardiomyocytes subjected to simulated ischemia/reperfusion in vitro.

[Cell Death & Disease] Scientists found that the level of mmu_circ_000338, a cardiac- necroptosis-associated circRNA, was reduced in hypoxia-reoxygenation exposed cardiomyocytes and ischemia-reperfusion-injured mice hearts.