The circRNA CNEACR Regulates Necroptosis of Cardiomyocytes through Foxa2 Suppression

Scientists found that the level of mmu_circ_000338, a cardiac- necroptosis-associated circRNA, was reduced in hypoxia-reoxygenation exposed cardiomyocytes and ischemia-reperfusion-injured mice hearts.
[Cell Death & Disease]
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Methyltransferase-Like 3 (METTL3) Attenuates Cardiomyocyte Apoptosis with Myocardial Ischemia-Reperfusion (I/R) Injury through miR-25-3p and miR-873-5p

Researchers showed that methyltransferase-like 3 (METTL3) was downregulated in mice ischemia-reperfusion (I/R) myocardial tissues and hypoxic/re-oxygenated (H/R) cardiomyocytes, and upregulation of METTL3 attenuated I/R and H/R-induced cell apoptosis.
[Cell Biology International]
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Histone Deacetylase HDAC4 Participates in the Pathological Process of Myocardial Ischemia-Reperfusion Injury via MEKK1/JNK Pathway by Binding to miR-206

Investigators defined the underlying role of histone deacetylase 4 (HDAC4) and miR-206 in the pathological process of myocardial ischemia-reperfusion injury (MIRI). Up-regulation of HDAC4 and down-regulation of miR-206 occurred in rat myocardial tissues and cardiomyocytes in MIRI.
[Cell Death Discovery]
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LncRNA-6395 Promotes Myocardial Ischemia-Reperfusion Injury in Mice through Increasing p53 Pathway

Scientists investigated the role of lncRNAs in myocardial ischemia-reperfusion injury. Overexpression of p53 canceled the inhibitory effects of lncRNA-6395 knockdown on cardiomyocyte apoptosis, whereas knockdown of p53 counteracted the apoptotic effects of lncRNA-6395 in cardiomyocytes.
[Acta Pharmacologica Sinica]
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Growth Differentiation Factor 11 Attenuates Cardiac Ischemia Reperfusion Injury via Enhancing Mitochondrial Biogenesis and Telomerase Activity

Ischemia/reperfusion (IR) injury mice with myocardial overexpression GDF11 exhibited a significantly smaller myocardial infarct size, less cardiac remodeling and dysfunction, fewer apoptotic cardiomyocytes, higher telomerase activity, longer telomeres, and higher ATP generation than IR mice treated with an adenovirus carrying a negative control plasmid.
[Cell Death & Disease]
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PSMB4 Inhibits Cardiomyocyte Apoptosis via Activating NF-κB Signaling Pathway during Myocardial Ischemia/Reperfusion Injury

In vitro, neonatal ventricle cardiomyocyte hypoxia/reoxygenation model was constructed to mimic myocardial ischemia/reperfusion. PSMB4 silence promoted cardiomyocyte apoptosis and IκBα expression, inhibited the activation of NF-κB.
[Journal of Molecular Histology]
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CircHIPK3 Regulates the Autophagy and Apoptosis of Hypoxia/Reoxygenation-Stimulated Cardiomyocytes via the miR-20b-5p/ATG7 axis

The authors examined the regulatory effect of circular RNA HIPK3 (circHIPK3) during myocardial ischemia/reperfusion and investigated its mechanism in cardiomyocyte autophagy and apoptosis.
[Cell Death Discovery]
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IP3R1 Regulates Ca2+ Transport and Pyroptosis through the NLRP3/Caspase-1 Pathway in Myocardial Ischemia/Reperfusion Injury

The adult rat cardiomyocytes were isolated and cultured to establish hypoxia/reperfusion (H/R) cell model. The expression of IP3R1 was downregulated or ERP44 was overexpressed in H/R-induced cells.
[Cell Death Discovery]
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Oxidized Phosphatidylcholines Trigger Ferroptosis in Cardiomyocytes during Ischemia/Reperfusion Injury

Cardiomyocyte viability, bioenergetic response and calcium transients were determined in the presence of oxidized phosphatidylcholines (OxPCs). Fragmented OxPCs resulted in a decrease in cell viability with POVPC and PONPC having the most potent cardiotoxic effect in both a concentration and time dependent manner.
[American Journal of Physiology-Heart and Circulatory Physiology]
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Heterodimerization with 5-HT2BR Is Indispensable for β2AR-Mediated Cardioprotection

Using pharmacological, genetic and biophysical protein-protein interaction approaches, scientists studied the cardioprotective effect of the β2-agonist, (R,R’)-4-methoxy-1-naphthylfenoterol, and explored the underlying mechanism in both in vivo in mice and cultured rodent cardiomyocytes insulted with doxorubicin, hydrogen peroxide or ischemia/reperfusion.
[Circulation Research]
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Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes

To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
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