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ACKR3 Regulates Platelet Activation and Ischemia-Reperfusion Tissue Injury

[Nature Communications] Researchers performed ischemia/reperfusion experiments in mice to assess the impact of genetic ACKR3 deficiency in platelets on tissue injury in ischemic myocardium and brain.

Losartan Protects Human Stem Cell-Derived Cardiomyocytes from Angiotensin II-Induced Alcoholic Cardiotoxicity

[Cell Death Discovery] Investigators established an in vitro model of alcoholic cardiomyopathy based on human induced pluripotent stem cell-derived cardiomyocytes.

Transplantation of MITO Cells, Mitochondria Activated Cardiac Progenitor Cells, to the Ischemic Myocardium of Mouse Enhances the Therapeutic Effect

[Scientific Reports] Investigators prepared mitochondria-activated stem cells (MITO cells) for use in transplantation. MITO cells, which were cardiac progenitor cells activated by the mitochondrial delivery of resveratrol with an anti-oxidant and mitochondrial activation effects, were successfully prepared using a mitochondrial targeting nanocarrier.

Whole Genome Sequencing Delineates Regulatory, Copy Number, and Cryptic Splice Variants in Early Onset Cardiomyopathy

[NPJ Genomic Medicine] Scientists analyzed whole-genome sequencing data in a discovery cohort of 209 pediatric cardiomyopathy patients and 1953 independent replication genomes and exomes and searched for protein-coding variants and non-coding variants predicted to affect the function or expression of genes.

Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells

[Stem Cells] Scientists review various modalities to evaluate the function of human stem cell-derived cardiac tissues and introduce heart-on-a-chip systems that can recapitulate physiological parameters of human pluripotent stem cell-derived cardiac tissues.

A Porcine Cholecystic Extracellular Matrix Conductive Scaffold for Cardiac Tissue Repair

[Journal of Biomedical Materials Research Part B-Applied Biomaterials] The authors addressed the contemporary need for a conductive biomimetic nanocomposite scaffold for cardiac tissue engineering by examining the use of a gold nanoparticle-incorporated porcine cholecystic ECM for the same.