Sevoflurane Preconditioning Promotes Mesenchymal Stem Cells to Relieve Myocardial Ischemia/Reperfusion Injury via TRPC6-Induced Angiogenesis

The authors investigated whether sevoflurane preconditioning could promote MSCs to attenuate myocardial I/R injury via transient receptor potential canonical channel 6 (TRPC6)-induced angiogenesis.
[Stem Cell Research & Therapy]
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Desmoglein 2 Regulates Cardiogenesis by Restricting Hematopoiesis in the Developing Murine Heart

Researchers proposed that cardiomyocyte-driven paracrine signaling, which likely involves Notch1, directs subsequent trans-differentiation of endo- and epicardial cells.
[Scientific Reports]
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Cardiac Aorta-Derived Extracellular Matrix Scaffold Enhances Critical Mediators of Angiogenesis in Isoproterenol-Induced Myocardial Infarction Mice

The authors investigated whether cardiomyocytes culturing on cardiac aorta-derived extracellular matrix scaffold had advantageous effects on cardiomyocytes survival and angiogenesis biomarkers’ expression.
[Journal of Materials Science-Materials in Medicine]
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Longeveron Announces Activation of Two New Clinical Sites in ELPIS II Trial of Lomecel-B for Hypoplastic Left Heart Syndrome (HLHS)

Longeveron, Inc. announced the activation of two new clinical sites for the currently enrolling ELPIS II Trial, evaluating Lomecel-B injection into the myocardium of infants with Hypoplastic Left Heart Syndrome, a rare and life-threatening congenital heart defect.
[Longeveron, Inc.]
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Development of Injectable Graphene Oxide/Laponite/Gelatin Hydrogel Containing Wharton’s Jelly Mesenchymal Stem Cells for Treatment of Oxidative Stress-Damaged Cardiomyocytes

Injectable GO/laponite/gelatin (GO-LG) hydrogel was developed and characterized. The results of cell viability showed that the optimal concentration of GO flasks to treat cells was 100 μg/ml.
[Colloids and Surfaces B-Biointerfaces]
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Repression of Osmr and Fgfr1 by miR-1/133a Prevents Cardiomyocyte Dedifferentiation and Cell Cycle Entry in the Adult Heart

Scientists demonstrated that suppression of FGFR1 and OSMR by miR-1/133a was instrumental to prevent cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.
[Science Advances]
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Cardiomyocyte microRNA-150 Confers Cardiac Protection and Directly Represses Proapoptotic Small Proline–Rich Protein 1A

Scientists demonstrated that potentially novel conditional cardiomyocyte–specific miR-150 knock out in mice worsened maladaptive cardiac remodeling after myocardial infarction.
[JCI Insight]
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Asiatic Acid Alleviates Ischemic Myocardial Injury in Mice by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism

Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours.
[Acta Pharmacologica Sinica]
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Genomic Instability in the Naturally and Prematurely Aged Myocardium

Scientists directly assessed the frequency of DNA damage of the murine myocardium during natural aging and in hearts from four mouse models of premature aging.
[Proceedings of the National Academy of Sciences of the United States of America]
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Identification of an Endogenous Glutamatergic Transmitter System Controlling Excitability and Conductivity of Atrial Cardiomyocytes

Research demonstrated that atrial cardiomyocytes have an intrinsic glutamatergic transmitter system, which regulated the generation and propagation of action potentials.
[Cell Research]
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Perinatal Angiogenesis from Pre-existing Coronary Vessels via DLL4–NOTCH1 Signaling

Scientists showed that, in late fetal development, the embryonic coronary plexus at the inner myocardium of the ventricles expressed the angiogenic signaling factors VEGFR3 and DLL4 and generates new coronary vessels in neonates.
[Nature Cell Biology]
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