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myocardium

EZH2 Mitigates the Cardioprotective Effects of Mesenchymal Stem Cell-Secreted Exosomes against Infarction via HMGA2-Mediated PI3K/AKT Signaling

[BMC Cardiovascular Disorders] Investigators probed the therapeutic effects of MSC-derived exosomes on myocardial fibrosis after myocardial infarction and possible mechanisms.

Doxorubicin Induces Cardiotoxicity in a Pluripotent Stem Cell Model of Aggressive B Cell Lymphoma Cancer Patients

[Basic Research in Cardiology] Researchers established an in vitro iPSC model of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and examined whether doxorubicin-treated ACT-iPSC cardiomyocytes could recapitulate the clinical features exhibited by patients.

Trimetazidine Enhances Myocardial Angiogenesis in Pressure Overload-Induced Cardiac Hypertrophy Mice through Directly Activating Akt and Promoting the Binding of HSF1 to VEGF-A Promoter

[Acta Pharmacologica Sinica] The authors investigated the effects of TMZ on myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice.

DeoxyATP Producing hiPSC Derived Cardiomyocyte to Restore Cardiac Function in Heart Failure

[Biophysical Journal] Scientists engineered ribonucleotide reductase overexpressing human-induced pluripotent stem cell-derived cardiomyocytes as a novel cell therapy strategy to improve contractility and regeneration in myocardial infarction.

PHLPP1 Deficiency Ameliorates Cardiomyocyte Death and Cardiac Dysfunction through Inhibiting Mcl-1 Degradation

[Cellular Signalling] Researchers found that PH domain leucine-rich repeat protein phosphatase1 (PHLPP1) deficiency enhanced Thr163 phosphorylation of Mcl-1, inhibited Mcl-1 degradation and maintained Mcl-1 protein expression level in myocardium and cardiomyocytes upon myocardial infarction or Dox treatment.

CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells

[Circulation] Investigators utilized mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyocyte ablation to investigate C-C chemokine ligand 17.

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