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myocytes

ATP-Sensitive Potassium Channels in Zebrafish Cardiac and Vascular Smooth Muscle

[Journal of Physiology] Using a comprehensive combination of genetically modified fish, electrophysiology, and gene expression analysis, scientists demonstrated that zebra fish cardiac myocytes and vascular smooth muscle expressed functional ATP-sensitive potassium channels channels of similar subunit composition, structure, and metabolic sensitivity to their mammalian counterparts.

The Cardiomyocyte Disrupts Pyrimidine Biosynthesis in Non-Myocytes to Regulate Heart Repair

[Journal of Clinical Investigation] Scientists showed that rescue of pyrimidine biosynthesis by administration of uridine or by genetic targeting of ENPP1/AMP pathway enhanced repair after cardiac injury.

MicroRNA-190b Expression Predicts a Good Prognosis and Attenuates the Malignant Progression of Pancreatic Cancer by Targeting MEF2C and TCF4

[Oncology Reports] Scientists examined the expression of miR‑190b in pancreatic cancer cell lines and tissues and evaluated its effects on cancer progression.

Desmoglein 2 Regulates Cardiogenesis by Restricting Hematopoiesis in the Developing Murine Heart

[Scientific Reports] Researchers proposed that cardiomyocyte-driven paracrine signaling, which likely involves Notch1, directs subsequent trans-differentiation of endo- and epicardial cells.

Negative Inotropic Mechanisms of β-Cardiotoxin in Cardiomyocytes by Depression of Myofilament ATPase Activity without Activation of the Classical β-Adrenergic Pathway

[Scientific Reports] The effects of beta-cardiotoxin on isolated cardiac myocyte functions, calcium homeostasis, the phosphorylation level of targeted proteins, and the myofibrillar ATPase activity were studied.

Distributed Synthesis of Sarcolemmal and Sarcoplasmic Reticulum Membrane Proteins in Cardiac Myocytes

[Basic Research in Cardiology] Researchers identified that the molecular machinery for membrane protein synthesis occurs throughout the cardiac myocyte, and enabled distributed synthesis of membrane proteins within sub-cellular niches where the synthesized protein functions using local mRNA pools trafficked, in part, by microtubules.

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