myocytes

[Cellular and Molecular Life Sciences] Investigators discuss the multifaceted heart problem in the course of Duchenne muscular dystrophy, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.

[Scientific Reports] Using type 2 diabetic db/db mice in vivo and isolated sinoatrial node (SAN) myocytes, scientists investigated whether blunted parasympathetic nervous system (PNS) effects on HR in type 2 diabetes mellitus were related to impaired responsiveness of the SAN to PNS agonists.

[Circulation Research] Cultured neonatal rat ventricular myocytes (NRVMs) were exposed to Tat-Beclin during simulated ischemia/reperfusion injury. ATG7 knockdown by siRNA in NRVMs was used to evaluate the role of autophagy.

[Circulation Research] The authors review the immune response to heart injury, its contribution to cardiac fibrosis, and the potential of immune modifying therapies to affect cardiac repair.

[NPJ Genomic Medicine] Scientists identified a genetic association between decreased expression of GDF5 and anthracycline-induced cardiotoxicity, and found that cell viability of GDF5-silenced human cardiac myocytes was significantly decreased in response to anthracycline treatment.

[Scientific Reports] Motor function was analyzed by three behavioral tests. Engraftment of human amniotic fluid stem cell in organs were assessed by flow cytometry and RNA scope.