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Natural Killer Cells

Triple-Negative Breast Cancer Cells Rely on Kinase-Independent Functions of CDK8 to Evade NK-Cell-Mediated Tumor Surveillance

[Cell Death & Disease] The authors used a murine model of orthotopic breast cancer to study the tumor-intrinsic role of cyclin-dependent kinase 8 (CDK8) in TNBC and linked CDK8 to programmed death-ligand 1 expression.

Immune and Nonimmune Mechanisms Mediate the Mental Stress-Induced Tumor Growth in a Xenograft Model of Breast Cancer

[Cell Death & Disease] Scientists applied unpredictable stress stimuli to breast tumor-bearing mice and established a xenograft model of breast cancer that suffered mental stress. This was followed by behavioral tests, tumor growth tracking, immune analysis, miRNA screening, and tumor cell proliferation analysis.

Perturbed NK Cell Homeostasis Associated with Disease Severity in Chronic Neutropenia

[Blood] Scientists used high-resolution flow- and mass cytometry to examine NK cell repertoires in 64 patients with neutropenia and 27 healthy age- and gender-matched donors.

IL12 Integrated into the CAR Exodomain Converts CD8+ T Cells to Poly-Functional NK-Like Cells with Superior Killing of Antigen-Loss Tumors

[Molecular Therapy] To reprogram the functional capacities specifically of engineered CAR T cells, the authors inserted IL12 into the extracellular moiety of a CD28-ζ CAR.

The Impact of Hypoxia on Immune State in Cancer

[Life Sciences] Infiltration and activity of CD8+ T cells is reduced in hypoxic conditions, whereas regulatory T cells and myeloid-derived suppressor cells show high activities.

Regeneration of Antigen-Specific T Cells by Using Induced Pluripotent Stem Cell (iPSC) Technology

[International Immunology] To apply the iPSC-based cell therapy in an allogeneic setting, the authors developed a method in which non-T cell-derived iPSCs were transduced with exogenous T cell receptor genes.

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