Natural Killer Cells

[Nanotechnology] Researchers designed a nanoliposome co-encapsulation of chlorin E6 and SB-3CT to realize significant antitumoral proliferation and metastasis efficacy after laser irradiation in A375 cells.

[JCI Insight] To rescue T and NK cells after UCART7, researchers created hematopoietic stem cells (HSCs) genetically deleted for CD7. CD7-KO HSCs were able to engraft immunodeficient mice and differentiate into T and NK cells lacking CD7 expression.

[Leukemia & Lymphoma] The authors investigated the prognostic significance of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) in t(8;21) acute myeloid leukemia (AML). A total of 47 t(8;21) AML patients were tested for TIM-3 expression by multi-parameter flow cytometry at diagnosis.

[Cell Reports] Scientists used genetic engineering to create human PSCs in which the majority of the polymorphic human leukocyte antigens, the main drivers of allogeneic rejection, were deleted.

[Scientific Reports] Scientists sought to understand how the programmed death ligand 1 inhibitor durvalumab and the immunomodulatory agent pomalidomide regulate immune cell activation and function in patients with relapsed/refractory multiple myeloma.

[Molecules and Cells] The authors detail the benefits of using iPSCs in natural killer cell immunotherapies and discuss the challenges that must be overcome before this approach becomes mainstream in the clinic.