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Neural Cell News

Microglia Promote Glioblastoma via mTOR-Mediated Immunosuppression of the Tumor Microenvironment

[Embo Journal] Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.

BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor–Mediated Calcium Signaling

[Journal of Immunology] lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13.

Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome

[Arthritis Research & Therapy] The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level.

Vagus Nerve Stimulation Even after Injury Ameliorates Cisplatin-Induced Nephropathy via Reducing Macrophage Infiltration

[Scientific Reports] To explore the role of the spleen and splenic macrophages, key players in the cholinergic anti-inflammatory pathway, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted.

The Pericyte Connectome: Spatial Precision of Neurovascular Coupling Is Driven by Selective Connectivity Maps of Pericytes and Endothelial Cells and Is Disrupted in Diabetes

[Cell Discovery] Pericytes connected predominantly to other neighboring pericytes and endothelial cells, and less to arteriolar smooth muscle cells, and not to surrounding neurons or glia.

Hypoxia-Preconditioned Placenta-Derived Mesenchymal Stem Cells Rescue Optic Nerve Axons via Differential Roles of Vascular Endothelial Growth Factor in an Optic Nerve Compression Animal Model

[Molecular Neurobiology] Scientists established a hypoxia-preconditioned strain using a hypoxic chamber. The human placenta–derived stem cells were exposed to short-term hypoxic conditions of 2.2% O2 and 5.5% CO2.

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