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neural cells

Odorant-Receptor-Mediated Regulation of Chemosensory Gene Expression in the Malaria Mosquito Anopheles gambiae

[Cell Reports] RNA-seq analyses comparing wild-type antennae to those ectopically expressing AgOR2 in olfactory receptor neurons indicated that nearly all AgOR transcripts were significantly downregulated, except for AgOR2.

Neuron-Epidermal Attachment Protects Hyper-Fragile Axons from Mechanical Strain

[Cell Reports] Researchers revealed a neuroprotective function of neuron-epidermal attachment in Caenorhabditis elegans.

Poly-Dipeptides Produced from C9orf72 Hexanucleotide Repeats Cause Selective Motor Neuron Hyperexcitability in ALS

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that proline-arginine poly-dipeptides generated from C9orf72 repeat expansions increased the intrinsic excitability in pyramidal neurons of the motor cortex but not in the principal neurons of the visual cortex, somatosensory cortex, or hippocampus.

A Single Factor Elicits Multilineage Reprogramming of Astrocytes in the Adult Mouse Striatum

[Proceedings of the National Academy of Sciences of the United States of America] Genetic lineage tracing and time-course analyses revealed that DLX2 enabled astrocytes to rapidly become ASCL1+ neural progenitor cells, which gave rise to neurons, astrocytes, and oligodendrocytes in the adult mouse striatum.

Cross-Talk between GABAergic Postsynapse and Microglia Regulate Synapse Loss after Brain Ischemia

[Science Advances] Scientists reported that at 24 hours after ischemia, microglia released brain-derived neurotrophic factor to downregulate glutamatergic and GABAergic synapses within the peri-infarct area.

Microglia Integration into Human Midbrain Organoids Leads to Increased Neuronal Maturation and Functionality

[Glia] Investigators described an approach to derive microglia from human induced pluripotent stem cells (iPSCs) and integrated them into iPSC-derived midbrain organoids.

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