neural cells

[Frontiers in Cell and Developmental Biology] Beneficial effects were observed with Rapamycin treatment as it decreased the gliotic response and prevented the development of newly formed blood vessels.

[Brain] Investigators reinforced the connection between aberrant cytosolic-to-endoplasmic reticulum acetyl-CoA flux and the development of an autistic-like phenotype.

[Acta Pharmacologica Sinica] Investigators describe in detail the damage-associated molecular patterns that induce or aggravate neuroinflammation in neurodegenerative diseases including mtDNA, mitochondrial unfolded protein response, mitochondrial reactive oxygen species, adenosine triphosphate, transcription factor A mitochondria, cardiolipin, cytochrome c, mitochondrial Ca2+ and iron.

[Cell Death & Differentiation] Scientists established a sequenced motor neurons (MN)-muscle co-differentiation system to engineer an in vitro functional 3D NMJ model for molecular studies and demonstrated that Cellular retinoic acid-binding protein 1 (CRABP1) in MNs contributes to NMJ formation and maintenance.

[Signal Transduction and Targeted Therapy] Scientists indicated that targeting IL6/JAK2/STAT3 signaling in activated microglia might be a promising new approach for inhibiting brain metastasis in NSCLC patients.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists tested whether perinatal intake of a multispecies probiotic could mitigate the abnormal emotional behavior in the juvenile and adult offspring of obese dams.