neural cells

[Molecular Psychiatry] Investigators used hiPSCs along with CRISPR-Cas9 gene editing to investigate the contribution of chromosome 21 candidate genes to Alzheimer’s disease-relevant neuronal phenotypes.

[EMBO Journal] USP33 was preferentially induced in glioma stem cells by hypoxia and interacts with HIF-2alpha, leading to its stabilization through deubiquitination.

[FASEB Journal] Checkpoint kinase 1 (ChK1)-mediated Cancerous Inhibitor of PP2A (CIP2A) overexpression drove inhibition of PP2A and activated STAT3, then led to reactive astrogliosis and neurodegeneration in vitro.

[Translational Stroke Research] The authors investigated the role of Mfn1-βIIPKC interaction in brain damage and neurological function in both in vivo and in vitro experimental subarachnoid hemorrhage models.

[Nature Reviews Neurology] The authors provide an overview of the involvement of astrocytes and microglia at major sites of pathology in progressive multiple sclerosis.

[EMBO Journal] Researchers identified USP33 as essential deubiquitinase that stabilized HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells.