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neural cells

Wasl Is Crucial to Maintain Microglial Core Activities during Glioblastoma Initiation Stages

[Glia] Scientists identified the underlying mechanism and showed that microglial morphology and functions were already impaired during glioma initiation stages.

Bone Morphogenetic Protein Receptor Inhibitors Suppress the Growth of Glioblastoma Cells

[Molecular and Cellular Biochemistry] Scientists utilized bone morphogenetic protein (BMP) inhibitors DMH1, JL5, and Ym155 to examine the role of BMP signaling on the growth of glioblastomas.

A Combined Cell and Gene Therapy Approach for Homotopic Reconstruction of Midbrain Dopamine Pathways Using Human Pluripotent Stem Cells

[Cell Stem Cell] Researchers showed that viral delivery of GDNF to the striatum, in conjunction with homotopic transplantation of human PSC-derived midbrain dopamine (mDA) neurons, recapitulated brain-wide mDA target innervation.

Dissection of the Polygenic Architecture of Neuronal Aβ Production Using a Large Sample of Individual iPSC Lines Derived from Alzheimer’s Disease Patients

[Nature Aging] To elucidate the polygenic architecture of Alzheimer’s disease (AD) phenotypes at a cellular level, the authors established iPSCs from 102 patients with AD, differentiated them into cortical neurons and conducted a genome-wide analysis of the neuronal production of amyloid β (Aβ).

Body Weight Regulation via MT1-MMP-Mediated Cleavage of GFRAL

[Nature Metabolism] The authors showed that membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) was an endogenous negative regulator of GDNF-family receptor a-like (GFRAL) in the context of obesity.

Activation-Induced Chromatin Reorganization in Neurons Depends on HDAC1 Activity

[Cell Reports] Researchers showed that stimulation of neurons caused condensation of large chromatin domains. This phenomenon can be observed in vitro in cultured rat hippocampal neurons as well as in vivo in the amygdala and hippocampal neurons.

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