Researchers tested whether a gene therapy strategy to reduce Siglec-3 (CD33) on microglia in Alzheimer’s disease could decrease amyloid beta plaque load.
[Human Molecular Genetics]
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Investigators showed that the 2-nitroimidazole doranidazole potentiated radiation-induced DNA damage in hypoxic glioma stem cells (GSCs) and conferred a significant survival benefit in mice harboring GSC-derived tumors in radiotherapy settings.
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Koike, N., Kota, R., Naito, Y., Hayakawa, N., Matsuura, T., Hishiki, T., Onishi, N., Fukada, J., Suematsu, M., Shigematsu, N., Saya, H., & Sampetrean, O. (2020). 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche. Communications Biology, 3(1), 1–13. https://doi.org/10.1038/s42003-020-01165-z Cite
Researchers demonstrated efficient brain-targeted delivery of apolipoprotein E 2 (ApoE2) encoding plasmid DNA using glucose transporter-1 targeted liposomes.
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Scientists found that Polycomb repressive complex 2 (PRC2) interacted with the nucleic acid–binding protein Ybx1. In neural progenitor cells, Ybx1 controlled self-renewal and neuronal differentiation.
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Researchers showed that neurons from the same lineage project to different columns under control of Down syndrome cell adhesion molecule in the fly brain.
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The authors sought to understand how apoptotic cells affect macrophage function in the context of a genetically tractable Drosophila model in which macrophages encountered excessive amounts of apoptotic cells.
[Cell Death & Disease]
During 3D organoid formation, the origin of iPSCs affected the levels of FOXA2 and LMX1A only in the first stages of neural differentiation, whereas in the 2D model, differences were detected at the levels of both early and late neural markers.
[International Journal of Molecular Sciences]
Investigators explored the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. They indicated that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions.
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Researchers demonstrated developmental differences in gene expression and accessible chromatin between progenitors and Müller glia (MG), primarily in neurogenic genes. Overexpression of Ascl1 was more effective in reprogramming immature MG, than mature MG, consistent with a more progenitor-like epigenetic landscape in the former.
Researchers focus on stem cell-based in vitro modeling of neurodevelopmental disorders, more specifically, the fundamentals and technical advancements in monolayer neuron and brain organoid cultures.
[Archives of Pharmacal Research]
Scientists examined whether epidermal growth factor receptor (EGFR) signaling affects bone morphogenic protein 4-induced differentiation of glioma stem cells and their response to the alkylating drug temozolomide.
[Experimental and Molecular Medicine]
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