The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
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Yang, Y., Cao, T.-T., Tian, Z.-M., Gao, H., Wen, H.-Q., Pang, M., He, W.-J., Wang, N.-X., Chen, Y.-Y., Wang, Y., Li, H., Lin, J.-W., Kang, Z., Li, M.-M., Liu, B., & Rong, L.-M. (2020). Subarachnoid transplantation of human umbilical cord mesenchymal stem cell in rodent model with subacute incomplete spinal cord injury: Preclinical safety and efficacy study. Experimental Cell Research, 112184. https://doi.org/10.1016/j.yexcr.2020.112184 Cite
Investigators determined the ability of the R-GSIK scaffold in supporting the effects of mesenchymal stem cells on motor function activity and inflammatory responses in an experimental traumatic brain injury model.
[Cell and Tissue Research]
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Sahab Negah, S., Shirzad, M. M., Biglari, G., Naseri, F., Hosseini Ravandi, H., Hassani Dooghabadi, A., & Gorji, A. (2020). Transplantation of R-GSIK scaffold with mesenchymal stem cells improves neuroinflammation in a traumatic brain injury model. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03247-0 Cite
By taking advantage of a human induced pluripotent stem cell-based model, scientists aimed to gain insights on the impact of amyotrophic lateral sclerosis (ALS) mutant FUS on the motoneuron proteome.
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Garone, M. G., Alfano, V., Salvatori, B., Braccia, C., Peruzzi, G., Colantoni, A., Bozzoni, I., Armirotti, A., & Rosa, A. (2020). Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding. Scientific Reports, 10(1), 11827. https://doi.org/10.1038/s41598-020-68794-6 Cite
The authors discuss recent progress in understanding how interneuron subtypes are generated in vivo, and how that progress is being applied to the generation of rodent and human cortical interneurons in vitro.
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Researchers report that transamniotic bone marrow-derived mesenchymal stem cell therapy for neural tube defects during early development may achieve beneficial functional recovery.
[Cell Death & Disease]
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Scientists observed remarkably high and dose-dependent SARS-CoV-2 specific antibody titers in mouse sera, as well as robust neutralization of both a pseudo-virus and wild-type virus.
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McKay, P. F., Hu, K., Blakney, A. K., Samnuan, K., Brown, J. C., Penn, R., Zhou, J., Bouton, C. R., Rogers, P., Polra, K., Lin, P. J. C., Barbosa, C., Tam, Y. K., Barclay, W. S., & Shattock, R. J. (2020). Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice. Nature Communications, 11(1), 3523. https://doi.org/10.1038/s41467-020-17409-9 Cite
The authors summarize international recommendations, discuss them in light of the first available data from patients with COVID-19 receiving immunotherapy and provide an overview of management approaches in the COVID-19 era.
[Nature Reviews Neurology]
IgG responses were detected in most patients in both severe and mild groups at nine days post onset and remained high level throughout the study. Antibodies cross-reactive to SARS-CoV and SARS-CoV-2 were detected in COVID-19 patients but not in MERS patients.
[Journal of Clinical Investigation]