NogoA-Expressing Astrocytes Limit Peripheral Macrophage Infiltration after Ischemic Brain Injury in Primates

Utilizing single-nuclei transcriptomics to characterize astrocytes after ischemic stroke in the visual cortex of the marmoset monkey, researchers observed nearly complete segregation between stroke and control astrocyte clusters.
[Nature Communications]
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Physiological Significance of WDR45, a Responsible Gene for β-Propeller Protein Associated Neurodegeneration (BPAN), in Brain Development

Scientists analyzed the physiological role of Wdr45 and pathophysiological significance of the gene abnormality during mouse brain development. Morphological and biochemical analyses revealed that Wdr45 was expressed in a developmental stage-dependent manner in mouse brain.
[Scientific Reports]
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Bioorthogonal Labeling of Transmembrane Proteins with Non-canonical Amino Acids Unveils Masked Epitopes in Live Neurons

Investigators reported the development of a complete labeling and imaging pipeline using genetic code expansion and non-canonical amino acids in neurons that allows to fluorescently label masked epitopes in target transmembrane proteins in live neurons, both in dissociated culture and organotypic brain slices.
[Nature Communications]
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Microglia Contribute to the Propagation of Aβ into Unaffected Brain Tissue

Using transplantation of wild-type (WT) neurons, the authors showed that amyloid beta (Aβ) entered WT grafts, and that this was accompanied by microglia infiltration.
[Nature Neuroscience]
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Long-Term Selective Stimulation of Transplanted Neural Stem/Progenitor Cells for Spinal Cord Injury Improves Locomotor Function

In cell transplantation therapy for spinal cord injury, grafted human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) differentiate into neurons. Scientists found that chemogenetic stimulation of hiPSC-derived neural cells enhancesd cell activity and neuron-to-neuron interactions in vitro.
[Cell Reports]
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Terahertz Exposure Enhances Neuronal Synaptic Transmission and Oligodendrocyte Differentiation In Vitro

Investigators reported that irradiation with a single-frequency Terahertz laser on mice cortical neuron cultures increased excitatory synaptic transmission and neuronal firing activities.
[iScience]
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Phosphatidylcholine Restores Neuronal Plasticity of Neural Stem Cells under Inflammatory Stres

Researchers demonstrated that phosphatidylcholine-enriched media enhanced neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. They also provided evidence that this phospholipid ameliorated the damage of neurons and modulated neuronal plasticity.
[Scientific Reports]
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Developmental Defects in Huntington’s Disease Show That Axonal Growth and Microtubule Reorganization Require NUMA1

Although the classic symptoms of Huntington’s disease manifest in adulthood, neural progenitor cell behavior is already abnormal by 13 weeks’ gestation. To determine how these developmental defects evolve, investigators turned to cell and mouse models.
[Neuron]
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Allele-Specific Targeting of Mutant Ataxin-3 by Antisense Oligonucleotides in SCA3-iPSC-Derived Neurons

The authors provided proof of principle that allele-specific lowering of polyQ-expanded ataxin-3 by selective antisense oligonucleotides was feasible and long lasting with sparing of wildtype ataxin-3 expression in a human cell culture model that was genetically identical to spinocerebellar ataxia type 3 (SCA3) patients.
[Molecular Therapy-Nucleic Acids]
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Transcriptomic Taxonomy and Neurogenic Trajectories of Adult Human, Macaque, and Pig Hippocampal and Entorhinal Cells

To investigate neurogenic potential and cellular diversity, scientists profiled single-nucleus transcriptomes in five hippocampal-entorhinal subregions in humans, macaques, and pigs.
[Neuron]
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Quantifying Neuronal Structural Changes Over Time Using Dynamic Morphometrics

Scientists review the methods of dynamic morphometrics, consisting of detailed quantification of structural changes of neurons over time, sampling and analyses, focusing on their applications to studies of activity-driven dendritogenesis in vertebrate systems.
[Trends in Neurosciences]
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