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neural cells

GPR177 in A-Fiber Sensory Neurons Drives Diabetic Neuropathic Pain via WNT-Mediated TRPV1 Activation

[Science Translational Medicine] Scientists reported that the orphan G protein–coupled receptor 177 (GPR177) in A-fiber neurons drove diabetic neuropathic pain via WNT5a-mediated activation of transient receptor potential vanilloid receptor-1 (TRPV1) ion channel.

Suppression of the Hyaluronic Acid Pathway Induces M1 Macrophages Polarization via STAT1 in Glioblastoma

[Cell Death Discovery] Scientists observed that disrupting glioblastoma hyaluronic acid synthesis or blocking HA binding to its receptor CD44 on macrophages increased the proportion of M1 macrophages by upregulating SIRPα in macrophages,

Microglia/Macrophage-Derived Human CCL18 Promotes Glioma Progression via CCR8-ACP5 Axis Analyzed in Humanized Slice Model

[Cell Reports] The authors studied the importance of CCL18, a cytokine expressed in human but not in rodent glioma-associated microglia/macrophages, as a modulator of glioma growth.

Promoter and Enhancer RNAs Regulate Chromatin Reorganization and Activation of miR-10b/HOXD Locus, and Neoplastic Transformation in Glioma

[Molecular Cell] The authors demonstrated that the entire miR-10b-hosting HOXD locus was activated in glioma via the cis-acting mechanism involving 3D chromatin reorganization and CTCF-cohesin-mediated looping.

Glioblastoma scRNAseq Shows Treatment-induced, Immune-dependent Rise In Mesenchymal Cancer Cells, and Structural Variants in Distal Neural Stem Cells

[Neuro-Oncology] Scientists used single-cell RNA-sequencing to analyze new and recurrent glioblastoma, and the nearby subventricular zone. They found four glioblastoma neural lineages were present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences.

VCP Suppresses Proteopathic Seeding in Neurons

[Molecular Neurodegeneration] Investigators performed a fluorescent cell sorting based genome-wide CRISPR-Cas9 screen in αS biosensors. αS and TDP-43 seeding activity under varied conditions was assessed using FRET/Flow biosensor cells or immunofluorescence for phosphorylated αS or TDP-43 in primary cultured neurons.

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