neural cells

[Cancer Letters] Scientists reported that tumor suppressor candidate 2 (TUSC2) protein expression is reduced/lost in glioblastoma compared to normal brain due to protein destabilization.

[Frontiers in Molecular Neuroscience] Investigators review existing data on the electrophysiological properties of neurons in human cortical organoids, as well as recent advances in the complexity of cortical organoid modeling that have led to improvements in functional maturation at single neuron and neuronal network levels.

[Cell Reports] Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Researchers probed the potential links among these cancer traits by inactivating TP53 in hESCs.

[ACS Applied Materials & interfaces] Scientists developed a CRISPR activation iPSC platform that constitutively expressed the dCas9-VPR system, which allowed robust activation of the proneural transcription factor NEUROD1 to rapidly induce neuronal differentiation within seven days.

[Advanced Science] A wireless-electrical stimulation method was proposed to direct the neural differentiation of adipose-derived MSCs (ADMSCs) based on the electromagnetic effect using a graphene film as a conductive scaffold.

[Biophysical Journal] Researchers developed a platform that utilized orthogonal photopatterning of stiffness and adhesivity gradients to fabricate individually accessible wells with discrete ECM conditions.