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neural cells

Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive without Neuroprotection in the Spinal Contusion Cavity

[Frontiers in Cellular Neuroscience] Using a rat cervical hemicontusion model, investigators evaluated the survival and integration of human iPSC-derived spinal motor neurons and oligodendrocyte progenitor cells.

Expression of the Transcription Factor PU.1 Induces the Generation of Microglia-Like Cells in Human Cortical Organoids

[Nature Communications] The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.

Transcriptional Programs Regulating Neuronal Differentiation Are Disrupted in DLG2 Knockout Human Embryonic Stem Cells and Enriched for Schizophrenia and Related Disorders Risk Variants

[Nature Communications] Scientists integrated human genetics with transcriptomic data from differentiation of human ESCs into cortical excitatory neurons.

SUPT4H1-Edited Stem Cell Therapy Rescues Neuronal Dysfunction in a Mouse Model for Huntington’s Disease

[NPJ Regenerative Medicine] Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.

Androgens Increase Excitatory Neurogenic Potential in Human Brain Organoids

[Nature] Investigators used brain organoids to show that although sex chromosomal complement had no observable effect on neurogenesis, sex steroids—namely androgens—led to increased proliferation of cortical progenitors and an increased neurogenic pool.

Astrocytes Display Cell Autonomous and Diverse Early Reactive States in Familial Amyotrophic Lateral Sclerosis

[Brain] The authors revealed that reactive transformation can occur cell autonomously in human ALS astrocytes and with a striking degree of early molecular and functional heterogeneity when comparing different disease-causing mutations.

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