Advantages and Prospects of Stem Cells in Nanotoxicology

The authors summarize the effects of nanomaterials on the proliferation and differentiation of ESCs, mesenchymal stem cells and neural stem cells.
[Chemosphere]
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Neuroendocrine Cells in Prostate Cancer Correlate with Poor Outcomes: A Systematic Review and Meta-Analysis.

Scientists review the prognostic utility of reporting neuroendocrine staining at prostate cancer diagnosis, and determine whether different reporting approaches impact the correlation between staining and patient outcome.
[BJU International]
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Tau Activates Microglia via the PQBP1-cGAS-STING Pathway to Promote Brain Inflammation

Tamoxifen-inducible and microglia-specific depletion of polyglutamine binding protein 1 (PQBP1) in primary culture in vitro and mouse brain in vivo showed that PQBP1 was essential for sensing-tau to induce nuclear translocation of nuclear factor κB (NFκB).
[Nature Communications]
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BH3-Only Proteins Puma and Beclin1 Regulate Autophagic Death in Neurons in Response to Amyloid-β

Investigators concluded that both Beclin1 and Puma played essential roles in the neuronal death caused by the induction of aberrant autophagy in Alzheimer’s disease and that targeting their interaction could be vital to understand the crosstalk of autophagy and apoptosis.
[Cell Death Discovery]
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Chemogenetic Modulation of Sensory Neurons Reveals Their Regulating Role in Melanoma Progression

Whether sensory neuronal activity is important for tumor progression remains unknown. Researchers suggested that sensory innervations regulate melanoma progression, indicating that manipulation of sensory neurons’ activity may provide a valuable tool to improve melanoma patients’ outcomes.
[Acta Neuropathologica Communications]
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Human Stem Cell-Derived GABAergic Neurons Functionally Integrate into Human Neuronal Networks

Researchers provided a proof-of-concept that human embryonic stem cell-derived neurons could integrate and modulate the activity of a human host neuronal network.
[Scientific Reports]
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Denali Therapeutics Announces Strategic Partner Takeda Exercises Option to Co-Develop and Co-Commercialize DNL593 (PTV:PGRN)

Denali Therapeutics, Inc. announced that its strategic partner Takeda Pharmaceutical Company Limited has exercised an option to co-develop and co-commercialize DNL593, an investigational, brain-penetrant progranulin replacement therapy for the potential treatment of frontotemporal dementia-granulin.
[Denali Therapeutics, Inc.]
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Schizophrenia Is Defined by Cell-Specific Neuropathology and Multiple Neurodevelopmental Mechanisms in Patient-Derived Cerebral Organoids

Scientists utilized patient-derived iPSCs to generate 3D cerebral organoids to model neuropathology of schizophrenia during its early-arising neurodevelopmental period.
[Molecular Psychiatry]
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Prilenia Receives Fast Track Designation for Pridopidine for the Treatment of Huntington’s Disease

Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, announced that the US FDA has granted Fast Track designation to pridopidine for development as a potential treatment for Huntington’s Disease.
[Prilenia Therapeutics B.V. (Business Wire, Inc.)]
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Murine Cerebral Organoids Develop Network of Functional Neurons and Hippocampal Brain Region Identity

Scientists developed a highly standardized, reproducible and fast murine brain organoid model starting from embryonic neural stem cells.
[iScience]
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Clinical Application of Mesenchymal Stem Cells in Rheumatic Diseases

In recent years, the application of MSCs in rheumatic diseases has received increasing attention. The authors review the clinical progress in MSC application for the treatment of rheumatic diseases.
[Stem Cell Research & Therapy]
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