By profiling sensory ganglia at single-cell resolution, researchers found that all somatosensory neuronal subtypes underwent a similar transcriptional response to peripheral nerve injury that both promoted axonal regeneration and suppressed cell identity.
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Scientists revealed that shortly after cortical stem cells have divided, daughter cells destined to self-renew underwent mitochondrial fusion, whereas those that retained high levels of mitochondria fission became neurons.
Importin α3–bound c-Fos and importin α3–deficient neurons were impaired in c-Fos nuclear import. Knockdown or dominant-negative inhibition of c-Fos or c-Jun in sensory neurons reduced neuropathic pain.
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Marvaldi, L., Panayotis, N., Alber, S., Dagan, S. Y., Okladnikov, N., Koppel, I., Pizio, A. D., Song, D.-A., Tzur, Y., Terenzio, M., Rishal, I., Gordon, D., Rother, F., Hartmann, E., Bader, M., & Fainzilber, M. (2020). Importin α3 regulates chronic pain pathways in peripheral sensory neurons. Science, 369(6505), 842–846. https://doi.org/10.1126/science.aaz5875 Cite
Scientists provide an overview of the role of astrocytes in CNS inflammation, highlighting recent discoveries on astrocyte subsets and the mechanisms that control them.
[Trends in Immunology]
Researchers tested whether a gene therapy strategy to reduce Siglec-3 (CD33) on microglia in Alzheimer’s disease could decrease amyloid beta plaque load.
[Human Molecular Genetics]
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Griciuc, A., Federico, A. N., Natasan, J., Forte, A. M., McGinty, D., Nguyen, H., Volak, A., LeRoy, S., Gandhi, S., Lerner, E. P., Hudry, E., Tanzi, R. E., & Maguire, C. A. (n.d.). Gene therapy for Alzheimer’s Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddaa179 Cite
Investigators showed that the 2-nitroimidazole doranidazole potentiated radiation-induced DNA damage in hypoxic glioma stem cells (GSCs) and conferred a significant survival benefit in mice harboring GSC-derived tumors in radiotherapy settings.
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Researchers demonstrated efficient brain-targeted delivery of apolipoprotein E 2 (ApoE2) encoding plasmid DNA using glucose transporter-1 targeted liposomes.
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Scientists found that Polycomb repressive complex 2 (PRC2) interacted with the nucleic acid–binding protein Ybx1. In neural progenitor cells, Ybx1 controlled self-renewal and neuronal differentiation.
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Researchers showed that neurons from the same lineage project to different columns under control of Down syndrome cell adhesion molecule in the fly brain.
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The authors sought to understand how apoptotic cells affect macrophage function in the context of a genetically tractable Drosophila model in which macrophages encountered excessive amounts of apoptotic cells.
[Cell Death & Disease]
During 3D organoid formation, the origin of iPSCs affected the levels of FOXA2 and LMX1A only in the first stages of neural differentiation, whereas in the 2D model, differences were detected at the levels of both early and late neural markers.
[International Journal of Molecular Sciences]