neural cells

[Stem Cell Reports] Investigators established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.

[Cold Spring Harbor Perspectives in Biology] Investigators found a set of four defined factors that could reprogram fibroblasts into iPSCs, which were shown to be molecularly and functionally equivalent to blastocyst-derived ESCs, thus essentially showing that defined factors could induce authentic reprogramming without the need of oocytes.

[Nature Communications] Investigators reported that the neuronal ECM could be remodeled frequently through mechanisms that involved endocytosis and recycling of ECM proteins.

[Science Advances] After bilateral brain injections, nanotubes showed preferential retention by tumors compared to normal brain and were taken up by glioblastoma cells through scavenger receptor binding and macropinocytosis.

[Journal of Neuroinflammation] Neuroinflammation is thought to be a cause of Alzheimer’s disease (AD), which is partly caused by inadequate mitophagy. As a receptor of mitophagy, the authors revealed the regulatory roles of optineurin (OPTN) on neuroinflammation in the pathogenesis of AD.

[npj Parkinson's Disease] The authors review current evidence for a vulnerability-stress model in which a relative reduction of dopaminergic projections to the ventral striatum and concomitant sensitization of postsynaptic neurons represent a predisposing (hypodopaminergic) vulnerability.