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neural cells

Mesenchymal Type Neuroblastoma Cells Escape ALK Inhibitors

[Cancer Research] Neuroblastoma cells can adopt a lineage committed adrenergic (ADRN) or an immature mesenchymal (MES) state. Investigators found that while ADRN cells resembled normal embryonal neuroblasts, MES cells resembled immature precursor cells which also lacked ALK expression.

MiRNA-132/212 Regulates Tight Junction Stabilization in Blood–Brain Barrier after Stroke

[Cell Death Discovery] The co-culture of endothelial cells with CRTC1-deficient neurons aggravated the cell vulnerability to hypoxia, also supporting the idea that miRNA-132/212 cluster was regulated by CRTC1 and acted as a crucial role in the mitigation of ischemic damage.

Targeting Glioblastoma Stem Cells: The First Step of Photodynamic Therapy

[Photodiagnosis and Photodynamic Therapy] Scientists present a brief review exclusively commenting on the therapeutic approaches to eliminate glioblastoma stem cells and on the research publications about this topic of glioblastoma stem cells in relation to photodynamic therapy.

STEM CELLS Translational Medicine’s Latest Young Investigator Award Winner Aims to Stop the Devastation Caused by Stroke

[Stem Cells Translational Medicine] Dr. Sara Palma-Tortosa is the 2021 recipient of the STEM CELLS Translational Medicine (SCTM) Young Investigator Award. The award honors a young researcher who served as the principal author of an article published in SCTM that, over the course of a year, is deemed to have the most impact.

Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8+ T-Cell Behaviors

[Neurology-Neuroimmunology & Neuroinflammation] Human CD8+ T lymphocytes from multiple sclerosis donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble ULBP4.

Regulation of Blood–Brain Barrier Integrity by Microbiome-Associated Methylamines and Cognition by Trimethylamine N-oxide

[Microbiome] Scientists used an integrated in vitro/in vivo approach to show that physiologically relevant concentrations of the dietary methylamine trimethylamine N-oxide enhanced blood-brain barrier integrity and protected it from inflammatory insult, acting through the tight junction regulator annexin A1.

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