Tag results:
neural cells
Neural Cell News
Harnessing Cerebral Organoids for Alzheimer’s Disease Research
[Current Opinion in Neurobiology] Scientists review the most recent advances in modeling Alzheimer's disease in organoids and other engineered 3D cell culture systems.
ESC & iPSC News
Functional Human Gastrointestinal Organoids Can Be Engineered from Three Primary Germ Layers Derived Separately from Pluripotent Stem Cells
[Cell Stem Cell] Researchers developed an organoid assembly approach starting with cells from the three primary germ layers—enteric neuroglial, mesenchymal, and epithelial precursors—that were derived separately from human PSCs.
ESC & iPSC News
$5.5 Million CIRM Grant to Fund Development of New Cervical Spinal Cord Injury Therapeutic
[UCI News] Aileen Anderson, director of the University of California Irvinc's Sue & Bill Gross Stem Cell Research Center and professor of physical medicine & rehabilitation, has been awarded a 30-month, $5.5 million grant from the California Institute for Regenerative Medicine (CIRM).
Neural Cell News
Traumatic Brain Injury in the Presence of Aβ Pathology Affects Neuronal Survival, Glial Activation and Autophagy
[Scientific Reports] The authors investigated cellular injury-induced processes in the presence of amyloid β (Aβ) pathology and exposed a co-culture system of cortical stem-cell derived astrocytes, neurons and oligodendrocytes to Aβ42 protofibrils prior to a mechanically induced scratch injury.
Neural Cell News
Altered Temporal Sequence of Transcriptional Regulators in the Generation of Human Cerebellar Granule Cells
[eLife] Investigators reported a rapid protocol for the derivation of the human ATOH1 lineage, the precursor of excitatory cerebellar neurons, from human pluripotent stem cells.
Neural Cell News
Axonal TDP-43 Condensates Drive Neuromuscular Junction Disruption through Inhibition of Local Synthesis of Nuclear Encoded Mitochondrial Proteins
[Nature Communications] The authors showed TDP-43 accumulation in intra-muscular nerves from amyotrophic lateral sclerosis (ALS) patients and in axons of human iPSC-derived motor neurons of ALS patients, as well as in motor neurons and neuromuscular junctions of a TDP-43 mislocalization mouse model.