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neural cells

Harnessing Cerebral Organoids for Alzheimer’s Disease Research

[Current Opinion in Neurobiology] Scientists review the most recent advances in modeling Alzheimer's disease in organoids and other engineered 3D cell culture systems.

Functional Human Gastrointestinal Organoids Can Be Engineered from Three Primary Germ Layers Derived Separately from Pluripotent Stem Cells

[Cell Stem Cell] Researchers developed an organoid assembly approach starting with cells from the three primary germ layers—enteric neuroglial, mesenchymal, and epithelial precursors—that were derived separately from human PSCs.

$5.5 Million CIRM Grant to Fund Development of New Cervical Spinal Cord Injury Therapeutic

[UCI News] Aileen Anderson, director of the University of California Irvinc's Sue & Bill Gross Stem Cell Research Center and professor of physical medicine & rehabilitation, has been awarded a 30-month, $5.5 million grant from the California Institute for Regenerative Medicine (CIRM).

Traumatic Brain Injury in the Presence of Aβ Pathology Affects Neuronal Survival, Glial Activation and Autophagy

[Scientific Reports] The authors investigated cellular injury-induced processes in the presence of amyloid β (Aβ) pathology and exposed a co-culture system of cortical stem-cell derived astrocytes, neurons and oligodendrocytes to Aβ42 protofibrils prior to a mechanically induced scratch injury.

Altered Temporal Sequence of Transcriptional Regulators in the Generation of Human Cerebellar Granule Cells

[eLife] Investigators reported a rapid protocol for the derivation of the human ATOH1 lineage, the precursor of excitatory cerebellar neurons, from human pluripotent stem cells.

Axonal TDP-43 Condensates Drive Neuromuscular Junction Disruption through Inhibition of Local Synthesis of Nuclear Encoded Mitochondrial Proteins

[Nature Communications] The authors showed TDP-43 accumulation in intra-muscular nerves from amyotrophic lateral sclerosis (ALS) patients and in axons of human iPSC-derived motor neurons of ALS patients, as well as in motor neurons and neuromuscular junctions of a TDP-43 mislocalization mouse model.

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