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neural cells

Altered H3 Histone Acetylation Impairs High-Fidelity DNA Repair to Promote Cerebellar Degeneration in Spinocerebellar Ataxia Type 7

[Cell Reports] Scientists performed chromatic immunoprecipitation sequencing ChIP-seq on cerebellum from spinocerebellar ataxia type 7 mice and observed increased H3K9-promoter acetylation in DNA repair genes, resulting in increased expression.

Circ-Hdgfrp3 Shuttles along Neurites and Is Trapped in Aggregates Formed by ALS-Associated Mutant FUS

[iScience] Investigators defined several features of circ-Hdgfrp3 and described interesting alterations occurring in motor neurons carrying ALS-associated FUS mutations. Through a highly sensitive in situ approach they described that circ-Hdgfrp3 trafficked along neurites, whilst upon oxidative stress it was retained in the perinuclear region.

AMPylation Profiling during Neuronal Differentiation Reveals Extensive Variation on Lysosomal Proteins

[iScience] Through a combination of chemical proteomics, gel-based separation of modified and unmodified proteins and an activity assay, the authors determined that the modified, lysosomal soluble form of exonuclease PLD3 increased dramatically during neuronal maturation and that AMPylation correlated with its catalytic activity.

NogoA-Expressing Astrocytes Limit Peripheral Macrophage Infiltration after Ischemic Brain Injury in Primates

[Nature Communications] Utilizing single-nuclei transcriptomics to characterize astrocytes after ischemic stroke in the visual cortex of the marmoset monkey, researchers observed nearly complete segregation between stroke and control astrocyte clusters.

Interrogation of the Microenvironmental Landscape in Spinal Ependymomas Reveals Dual Functions of Tumor-Associated Macrophages

[Nature Communications] Scientists performed single-cell RNA-sequencing analysis of three spinal ependymoma subtypes to dissect the microenvironmental landscape of spinal ependymomas and revealed tumor-associated macrophage subsets with distinct functional phenotypes.

Potential Role of Growth Factors Controlled Release in Achieving Enhanced Neuronal Trans-Differentiation from Mesenchymal Stem Cells for Neural Tissue Repair and Regeneration

[Molecular Neurobiology] The authors analyze the various carriers that have been employed for the release of growth factors in an orderly fashion and their constituents, along with the advantages and the limitations they pose in delivering the growth factors for facilitating the process of neuronal transdifferentiation.

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