neural cells

[Open Biology] Scientists showed that the deficiency of miRNA-22a, an endothelial-enriched miRNA, caused dramatic pathfinding defects both in intersegmental vessels and primary motor neurons in zebrafish embryos.

[Nature Communications] The authors investigated if focal ablation of astrocytes were sufficient to disrupt the blood-brain barrier in mice. Targeted two-photon chemical apoptotic ablation of astrocytes induced a plasticity response whereby surrounding astrocytes extended processes to cover vascular vacancies.

[Nature Neuroscience] Scientists found that a longer duration of epilepsy was associated with a sharp decline in neuronal production and persistent numbers in astrogenesis.

[Neuron] To improve understanding of transcriptomic heterogeneity in glia during Alzheimer’s disease (AD), the authors used single-nuclei RNA sequencing to characterize astrocytes and oligodendrocytes from apolipoprotein Ɛ2/3 human AD and age- and genotype-matched non-symptomatic brains.

[Science Advances] Researchers identified deubiquitinase cylindromatosis (CYLD) as a negative regulator of dopamine neuron survival, and inhibition of CYLD could potentially be beneficial in Parkinson’s disease by lowering parkin interacting substrate ZNF746 levels and promoting mitochondrial biogenesis.

[Neuroscience and Biobehavioral Reviews] The authors summarize current knowledge on the impact of astrocyte and microglia activity on behavioral outcomes, with a specific focus on brain areas relevant to higher cognitive control, reward-seeking, and circadian regulation.