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neural cells

Extracellular Vesicles from Hypoxia-Preconditioned Microglia Promote Angiogenesis and Repress Apoptosis in Stroke Mice via the TGF-β/Smad2/3 Pathway

[Cell Death & Disease] By exposing bEnd.3 endothelial cells and primary cortical neurons to oxygen−glucose deprivation (OGD), the impact of extracellular vesicles from OGD-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and TUNEL staining was assessed.

Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome

[Molecular Neurobiology] Investigators evaluated the effects of human umbilical cord mesenchymal stem cell-conditioned medium in a new in vitro model of neurons differentiated from Dravet syndrome patient-derived iPSCs.

Cromolyn Platform Suppresses Fibrosis and Inflammation, Promotes Microglial Phagocytosis and Neurite Outgrowth

[Scientific Reports] Scientists utilized cromolyn, a mast cell inhibitor with anti-inflammatory capabilities, and its fluorinated analogue F-cromolyn to study fibrosis-related protein regulation and secretion downstream of neuroinflammation and their ability to promote microglial phagocytosis and neurite outgrowth.

Genetic Inhibition of RIPK3 Ameliorates Functional Outcome in Controlled Cortical Impact Independent of Necroptosis

[Cell Death & Disease] Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.

Gene-Corrected p.A30P SNCA Patient-Derived Isogenic Neurons Rescue Neuronal Branching and Function

[Scientific Reports] Using two clonal gene-corrected isogenic cell lines, investigators identified image-based phenotypes showing impaired neuritic processes. The pathological neurons displayed impaired neuronal activity, reduced mitochondrial respiration, and transcriptional alterations in lipid metabolism.

Competitive Binding of E3 Ligases TRIM26 and WWP2 Controls SOX2 in Glioblastoma

[Nature Communications] Investigators identified E3 ligase competition as a critical mechanism of SOX2 regulation, with functional consequences for glioblastoma stem cells identity and maintenance.

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