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neural cells

Glial and Myeloid Heterogeneity in the Brain Tumor Microenvironment

[Nature Reviews Cancer] The authors discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.

CCR2 Deficiency Alters Activation of Microglia Subsets in Traumatic Brain Injury

[Cell Reports] Researchers defined the heterogeneity of microglia and macrophage phenotypes during traumatic brain injury (TBI) in wild-type mice and Ccr2−/− mice, which lacked macrophage influx following TBI and were resistant to brain damage.

Phenotypic Plasticity of Myeloid Cells in Glioblastoma Development, Progression, and Therapeutics

[Oncogene] The authors revisit biological characteristics and functions of infiltrating myeloid cells and discuss the recent advances in immunotherapies targeting infiltrating myeloid cells in glioblastoma .

Neuronal Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral Sclerosis Is Developmentally Regulated

[Scientific Reports] Scientists used human iPSCs and generated a developmental timeline by differentiating sporadic amyotrophic lateral sclerosis (sALS) iPSCs to neural progenitors and to motor neurons and comparing mitochondrial parameters with familial ALS and control cells at each developmental stage.

Limosilactobacillus reuteri ATCC 6475 Metabolites Upregulate the Serotonin Transporter in the Intestinal Epithelium

[Beneficial Microbes] The authors reported that the intestinal commensal microbe Limosilactobacillus reuteri ATCC PTA 6475 secretes 83.4 mM ethanol. Consistent with the activity of L. reuteri alcohol dehydrogenases, they found that L. reuteri tolerated various levels of ethanol.

Robust Neuronal Differentiation of Human iPSC-Derived Neural Progenitor Cells Cultured on Densely-Spaced Spiky Silicon Nanowire Arrays

[Scientific Reports] Researchers presented human patient induced pluripotent stem cell-derived neurons cultured on densely-spaced spiky silicon nanowire arrays which showed mature electrophysiological characteristics after only 20 days of culturing.

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