neural cells

[Scientific Reports] POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes. Increased Oct-1Z expression levels in differentiating human neuroblasts activated genes controlling stress response, neural cell differentiation, brain formation, and organogenesis.

[Cell] Researchers found that microglia exposed to α-syn established a cellular network through the formation of F-actin-dependent intercellular connections, which transfered α-syn from overloaded microglia to neighboring naive microglia where the α-syn cargo got rapidly and effectively degraded.

[nan] PathMaker Neurosystems, Inc. announced that it was awarded a Phase I STTR grant from NIH’s National Institute of Neurological Disorders and Stroke. The $371,000 award will enable the completion of key pre-clinical studies evaluating the effect of treatment with PathMaker’s breakthrough technology for motor neuron hyperexcitability suppression in transgenic ALS mice.

[International Journal of Oncology] As the tumor microenvironment is typically acidic due to increased glycolysis and consequently leads to an increased production of lactic acid in tumor cells, the role of acid‑sensing ion channel 1a (ASIC1a), an acid sensor, was explored as a tumor suppressor in gliomagenesis and stemness.

[International Journal of Developmental Biology] Scientists investigated the neuronal reprogramming capacity of CEND1 and/or Neurogenin-2 (NEUROG2) upon their overexpression on primary human adult cortical astrocytes.

[Journal of Cellular and Molecular Medicine] Researchers investigated whether co-grafting of MSCs could improve the survival and reinnervation ability of dopaminergic precursors transplanted in animal models of Parkinson's disease.