neural cells

[JCI Insight] Researchers reported CD109/STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of glioma stem cells and as a mediator of chemoresistance.

[Communications Biology] Linear, adhered rat and human 3D neuronal-astrocyte cultures were developed to enable the study of aggregation and sorting of these cells. An in silico model of the contraction, clustering, and cell sorting in the 3D cultures was also developed.

[Trends in Neurosciences] The authors highlight multiple layers of disinhibition across cortical circuits that regulate behavior and serve to maintain an excitation/inhibition balance.

[Cell & Bioscience] Researchers describe the cellular and molecular properties of urine-derived stem cells, their differentiation potency, different reprogramming methods for the generation of iPSCs/induced neural stem cells, and their potential applications in modeling neurological diseases.

[Science Translational Medicine] Using patient-derived iPSCs, researchers generated a midbrain dopaminergic neuron model of dopamine transporter deficiency syndrome that exhibited marked impairment of DAT activity, apoptotic neurodegeneration associated with TNFα-mediated inflammation, and dopamine toxicity.

[Nature Communications] Researchers showed that 16pdel iPSC-derived dopaminergic neurons have increased soma size and synaptic marker expression compared to isogenic control lines.