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neural progenitor cells

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Scientists explored miRNA profiles of CB-MSCs during differentiation into motor neuron-like cells.

Genome-Wide Maps of Nucleolus Interactions Reveal Distinct Layers of Repressive Chromatin Domains

[Nature Communications] The authors established DamID- and HiC-based methodologies to generate accurate genome-wide maps of nucleolar associated domains in ESCs and neural progenitor cells, revealing layers of genome compartmentalization with distinct, repressive chromatin states based on the interaction with the nucleolus, nuclear lamina, or both.

Pulmonary and Neurologic Effects of Mesenchymal Stromal Cell Extracellular Vesicles in a Multifactorial Lung Injury Model

[American Journal of Respiratory and Critical Care Medicine] Researchers investigated whether a multifactorial neonatal mouse model of lung injury perturbed neural progenitor cell function and assessed the ability of human umbilical cord-derived MSC extracellular vesicles to mitigate pulmonary and neurologic injury.

Glycosphingolipids in Human Embryonic Stem Cells and Breast Cancer Stem Cells, and Potential Cancer Therapy Strategies Based on Their Structures and Functions

[Glycoconjugate Journal] The authors indicate that GD3 synthase contributes to gefitinib resistance in epidermal growth factor receptor-positive breast cancer cells, and is a potentially useful therapeutic target in drug-resistant breast cancers.

A Single Factor Elicits Multilineage Reprogramming of Astrocytes in the Adult Mouse Striatum

[Proceedings of the National Academy of Sciences of the United States of America] Genetic lineage tracing and time-course analyses revealed that DLX2 enabled astrocytes to rapidly become ASCL1+ neural progenitor cells, which gave rise to neurons, astrocytes, and oligodendrocytes in the adult mouse striatum.

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