Physical Exercise Promotes Integration of Grafted Cells and Functional Recovery in an Acute Stroke Rat Model

Neural progenitor cell (NPC) transplantation, combined with physical exercise, showed significant improvement in both structural and behavioral outcomes in stroke-damaged rats.
[Stem Cell Reports]
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FASN-Dependent De Novo Lipogenesis Is Required for Brain Development

Scientists established a role of de novo lipogenesis for mouse and human brain development and identified a link between progenitor-cell polarity and lipid metabolism.
[Proceedings of the National Academy of Sciences of the United States of America]
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Ddx20, an Olig2 Binding Factor, Governs the Survival of Neural and Oligodendrocyte Progenitor Cells via Proper Mdm2 Splicing and p53 Suppression

Researchers demonstrated that a novel Olig2-binding protein, DEAD-box helicase 20 (Ddx20), was indispensable for the survival of neural progenitor cells and oligodendrocyte progenitor cells.
[Cell Death & Differentiation]
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Developmental Defects in Huntington’s Disease Show That Axonal Growth and Microtubule Reorganization Require NUMA1

Although the classic symptoms of Huntington’s disease manifest in adulthood, neural progenitor cell behavior is already abnormal by 13 weeks’ gestation. To determine how these developmental defects evolve, investigators turned to cell and mouse models.
[Neuron]
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CHD8 Safeguards Early Neuroectoderm Differentiation in Human ESCs and Protects from Apoptosis during Neurogenesis

Investigators generated CHD8 knockout human ESCs by CRISPR/Cas9 technology and characterized the effect of loss-of-function of CHD8 on pluripotency maintenance and lineage determination by utilizing efficient directed differentiation protocols.
[Cell Death & Disease]
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Impaired Neural Differentiation of MPS IIIA Patient Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells

Investigators demonstrated the generation of Mucopolysaccharidosis type IIIA (MPS IIIA) iPSCs, and neural progenitor cells, the latter of which display reduced proliferation and neurogenic capacity.
[Molecular Genetics and Metabolism Reports]
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A Cis-Acting Structural Variation at the ZNF558 Locus Controls a Gene Regulatory Network in Human Brain Development

Scientists identified a KRAB-ZFP transcription factor, ZNF558, that was expressed in human but not chimpanzee forebrain neural progenitor cells.
[Cell Stem Cell]
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A Polycomb Domain Found in Committed Cells Impairs Differentiation When Introduced into PRC1 in Pluripotent Cells

ESCs expressing a chimeric CBX7 were impaired in their ability to properly form embryoid bodies and neural progenitor cells and showed reduced activation of lineage-specific genes across differentiation.
[Molecular Cell]
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Cend1 and Neurog2 Efficiently Reprogram Human Cortical Astrocytes to Neural Precursor Cells and Induced-Neurons

Scientists investigated the neuronal reprogramming capacity of CEND1 and/or Neurogenin-2 (NEUROG2) upon their overexpression on primary human adult cortical astrocytes.
[International Journal of Developmental Biology]
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Robust Neuronal Differentiation of Human iPSC-Derived Neural Progenitor Cells Cultured on Densely-Spaced Spiky Silicon Nanowire Arrays

Researchers presented human patient induced pluripotent stem cell-derived neurons cultured on densely-spaced spiky silicon nanowire arrays which showed mature electrophysiological characteristics after only 20 days of culturing.
[Scientific Reports]
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High-Content Image-Based Analysis and Proteomic Profiling Identifies Tau Phosphorylation Inhibitors in a Human iPSC-Derived Glutamatergic Neuronal Model of Tauopathy

Scientists used iPSCs from a patient carrying a p.A152T tau variant to create a robust, functional cellular assay system for probing pathophysiological tau accumulation and phosphorylation.
[Scientific Reports]
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