[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.
[Nature Communications] The authors established DamID- and HiC-based methodologies to generate accurate genome-wide maps of nucleolar associated domains in ESCs and neural progenitor cells, revealing layers of genome compartmentalization with distinct, repressive chromatin states based on the interaction with the nucleolus, nuclear lamina, or both.
[American Journal of Respiratory and Critical Care Medicine] Researchers investigated whether a multifactorial neonatal mouse model of lung injury perturbed neural progenitor cell function and assessed the ability of human umbilical cord-derived MSC extracellular vesicles to mitigate pulmonary and neurologic injury.
[Glycoconjugate Journal] The authors indicate that GD3 synthase contributes to gefitinib resistance in epidermal growth factor receptor-positive breast cancer cells, and is a potentially useful therapeutic target in drug-resistant breast cancers.
[Proceedings of the National Academy of Sciences of the United States of America] Genetic lineage tracing and time-course analyses revealed that DLX2 enabled astrocytes to rapidly become ASCL1+ neural progenitor cells, which gave rise to neurons, astrocytes, and oligodendrocytes in the adult mouse striatum.