Tag results:

neural progenitor cells

Developmental Defects in Huntington’s Disease Show That Axonal Growth and Microtubule Reorganization Require NUMA1

[Neuron] Although the classic symptoms of Huntington’s disease manifest in adulthood, neural progenitor cell behavior is already abnormal by 13 weeks’ gestation. To determine how these developmental defects evolve, investigators turned to cell and mouse models.

CHD8 Safeguards Early Neuroectoderm Differentiation in Human ESCs and Protects from Apoptosis during Neurogenesis

[Cell Death & Disease] Investigators generated CHD8 knockout human ESCs by CRISPR/Cas9 technology and characterized the effect of loss-of-function of CHD8 on pluripotency maintenance and lineage determination by utilizing efficient directed differentiation protocols.

Impaired Neural Differentiation of MPS IIIA Patient Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells

[Molecular Genetics and Metabolism Reports] Investigators demonstrated the generation of Mucopolysaccharidosis type IIIA (MPS IIIA) iPSCs, and neural progenitor cells, the latter of which display reduced proliferation and neurogenic capacity.

A Cis-Acting Structural Variation at the ZNF558 Locus Controls a Gene Regulatory Network in Human Brain Development

[Cell Stem Cell] Scientists identified a KRAB-ZFP transcription factor, ZNF558, that was expressed in human but not chimpanzee forebrain neural progenitor cells.

A Polycomb Domain Found in Committed Cells Impairs Differentiation When Introduced into PRC1 in Pluripotent Cells

[Molecular Cell] ESCs expressing a chimeric CBX7 were impaired in their ability to properly form embryoid bodies and neural progenitor cells and showed reduced activation of lineage-specific genes across differentiation.

Cend1 and Neurog2 Efficiently Reprogram Human Cortical Astrocytes to Neural Precursor Cells and Induced-Neurons

[International Journal of Developmental Biology] Scientists investigated the neuronal reprogramming capacity of CEND1 and/or Neurogenin-2 (NEUROG2) upon their overexpression on primary human adult cortical astrocytes.

Popular