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neural progenitor cells

Generation of Caudal-Type Serotonin Neurons and Hindbrain-Fate Organoids from hPSCs

[Stem Cell Reports] Scientists proposed a novel strategy to generate hindbrain serotonin (5-HT) neurons from human PSCs, which involved the formation of ventral-type neural progenitor cells and stimulation of the hindbrain 5-HT neural development.

Hypoproliferative Human Neural Progenitor Cell Xenografts Survived Extendedly in the Brain of Immunocompetent Rats

[Stem Cell Research & Therapy] Neuron-restricted neural progenitor cells (NPCs) were derived from human embryonic stem cells, propagated for different passages, and then transplanted into the brain of immunocompetent rats without immunosuppressants.

Transcriptome Analysis of MBD5-Associated Neurodevelopmental Disorder (MAND) Neural Progenitor Cells Reveals Dysregulation of Autism-Associated Genes

[Scientific Reports] Researchers created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and conducted RNA-seq to identify differentially expressed genes (DEGs) and the biological processes and pathways altered in MAND.

A Selective Cytotoxic Adenovirus Vector for Concentration of Pluripotent Stem Cells in Human Pluripotent Stem Cell-Derived Neural Progenitor Cells

[Scientific Reports] Researchers investigated whether a generation of an adenovirus vectors that possess a suicide gene allow for detection of undifferentiated human iPSCs in preparations of human iPSC-derived neural progenitor cells, which have been expected to treat neurological disorders.

Interleukin-1β-Induced Matrix Metalloproteinase-3 via ERK1/2 Pathway to Promote Mesenchymal Stem Cell Migration

[PLOS ONE] Scientists proposed that IL-1β influences human umbilical cord Wharton's jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.

Cell-Type-Specific Effects of Genetic Variation on Chromatin Accessibility during Human Neuronal Differentiation

[Nature Neuroscience] Researchers identified significant genetic effects on 988/1,839 neuron/progenitor regulatory elements, with highly cell-type and temporally specific effects.

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