Using mouse in utero electroporation technique and in vitro human neural stem cell (NSC) differentiation models including cerebral organoids, investigators showed that regulator of cell cycle modulated NSC self-renewal and neuronal differentiation by affecting cell cycle regulation and spindle orientation.
The authors formed encapsulated, transplantable neuronal networks of regionally matched cervical spinal motor neurons, interneurons, and oligodendrocyte progenitor cells derived through trunk-biased neuromesodermal progenitors.
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Scientists used human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landscape in a relevant developmental context.
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Researchers evaluated changes in extracellular vesicles morphology, concentration, and miRNA and protein expression in culture supernatants during the differentiation of iPSCs into neural lineage cells, for application in regenerative medicine for Parkinson’s disease.
[Journal of Bioscience and Bioengineering]
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Using patient-derived human induced pluripotent stem cell-forebrain cerebral organoids (hCOs), researchers identified both neural stem cell proliferation and neuronal maturation abnormalities in neurofibromatosis type 1-total gene deletion hCOs.
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Wegscheid, M. L., Anastasaki, C., Hartigan, K. A., Cobb, O. M., Papke, J. B., Traber, J. N., Morris, S. M., & Gutmann, D. H. (2021). Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Cell Reports, 36(1). https://doi.org/10.1016/j.celrep.2021.109315 Cite
Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.
[Nature Biomedical Engineering]
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Kim, J., Lee, K.-T., Lee, J. S., Shin, J., Cui, B., Yang, K., Choi, Y. S., Choi, N., Lee, S. H., Lee, J.-H., Bahn, Y.-S., & Cho, S.-W. (2021). Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier. Nature Biomedical Engineering, 1–17. https://doi.org/10.1038/s41551-021-00743-8 Cite
Researchers report on the development of an enhanced synergistic combination therapy comprising polyacetal–curcumin nanoconjugate and neural stem cells derived from induced pluripotent stem cells + mesenchymal stem cells treatment as a treatment option for severe sub-acute traumatic spinal cord injury.
[International Journal of Molecular Sciences]
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Epothilone D could promote the neuronal differentiation of neural stem cells by upregulating Apol8, which might provide a promising therapeutic target for spinal cord injury repair.
[Stem Cell Research & Therapy]
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Researchers discuss the potential of prostaglandins as candidates for the development of new therapeutic drugs for motor neuron diseases.
[Cellular and Molecular Neurobiology]
Researchers describe the cellular and molecular properties of urine-derived stem cells, their differentiation potency, different reprogramming methods for the generation of iPSCs/induced neural stem cells, and their potential applications in modeling neurological diseases.
[Cell & Bioscience]
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Scientist found that FGF13A, the nuclear isoform of FGF13, is involved in the maintenance of neural stem cells and the suppression of neuronal differentiation during post-natal hippocampal development.
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