Dystonia-Specific Mutations in THAP1 Alter Transcription of Genes Associated with Neurodevelopment and Myelin

Scientists established a pipeline for characterizing an allelic series of dystonia-specific mutations. They used this strategy to investigate the molecular consequences of genetic variation in THAP1, which encoded a transcription factor linked to neural differentiation.
[American Journal of Human Genetics]
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Introducing Dorsoventral Patterning in Adult Regenerating Lizard Tails with Gene-Edited Embryonic Neural Stem Cells

Neural-stem cells were isolated from parthenogenetic lizard embryos, rendered unresponsive to Hedgehog signaling via CRISPR/Cas9 gene knockout of smoothened, and implanted back into clonally-identical adults to regulate tail regeneration.
[Nature Communications]
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Interventional Strategies for Parkinson Disease: Can Neural Precursor Cells Forge a Path Ahead?

The authors discuss the role of PSC-derived neural precursor cells in rat models of MPTP-induced Parkinson’s disease following intranasal injections.
[ACS Chemical Neuroscience]
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Targeting EYA2 Tyrosine Phosphatase Activity in Glioblastoma Stem Cells Induces Mitotic Catastrophe

The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.
[Journal of Experimental Medicine]
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Hypoxic Postconditioning Promotes Neurogenesis by Modulating the Metabolism of Neural Stem Cells after Cerebral Ischemia

Researchers investigated whether hypoxic postconditioning (HPC) could promote neurogenesis after ischemic stroke, and to investigate the role of neuronal stem cell metabolism in HPC-induced neuroprotection.
[Experimental Neurology]
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Cend1 and Neurog2 Efficiently Reprogram Human Cortical Astrocytes to Neural Precursor Cells and Induced-Neurons

Scientists investigated the neuronal reprogramming capacity of CEND1 and/or Neurogenin-2 (NEUROG2) upon their overexpression on primary human adult cortical astrocytes.
[International Journal of Developmental Biology]
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Human Microglia States Are Conserved across Experimental Models and Regulate Neural Stem Cell Responses in Chimeric Organoids

Xenotransplantation of human microglia into cerebral organoids allowed us to characterize key transcriptional programs of developing microglia in vitro and revealed that microglia induced transcriptional changes in neural stem cells and decrease interferon signaling response genes.
[Cell Stem Cell]
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CRISPR/Cas9 Mediated Gene Correction Ameliorates Abnormal Phenotypes in Spinocerebellar Ataxia Type 3 Patient-Derived Induced Pluripotent Stem Cells

Spinocerebellar ataxia type 3 (SCA3)-iPSCs could be corrected by the replacement of the abnormal CAG expansions with normal repeats using CRISPR/Cas9-mediated homologous recombination strategy. Corrected SCA3-iPSCs retained pluripotent and normal karyotype, which could be differentiated into a neural stem cell and neuronal cells.
[Translational Psychiatry]
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Microglial ASD-Related Genes Are Involved in Oligodendrocyte Differentiation

The authors investigated the role of microglial chromodomain-helicase DNA-binding protein 8 and tuberous sclerosis complex 2 in cytokine expression, phagocytosis activity, and neuro/gliogenesis from neural stem cells in vitro.
[Scientific Reports]
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Engineered Basic Fibroblast Growth Factor-Overexpressing Human Umbilical Cord-Derived Mesenchymal Stem Cells Improve the Proliferation and Neuronal Differentiation of Endogenous Neural Stem Cells and Functional Recovery of Spinal Cord Injury by Activating the PI3K-Akt-GSK-3β Signaling Pathway

Researchers investigated the safety for clinic use and therapeutic effects of basic fibroblast growth factor-overexpressing human umbilical cord-derived MSCs in mice with completely transected spinal cord injury.
[Stem Cell Research & Therapy]
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Engineered Human Induced Pluripotent Cells Enable Genetic Code Expansion in Brain Organoids

Scientists demonstrated that genomic integration of expression cassettes for a pyrrolysyl-tRNA synthetase, pyrrolysyl-tRNA and the target protein of interest enables site-specific incorporation of a non-canonical amino acid in response to amber stop codons.
[Chembiochem]
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