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neural stem cells

Phenotypic and Molecular States of IDH1 Mutation-Induced CD24-Positive Glioma Stem-Like Cells

[Neoplasia] The authors demonstrated that induction of a CD24-positive population is one mechanism by which IDH-mutant tumors acquired stem-like properties.

Glioblastoma scRNAseq Shows Treatment-induced, Immune-dependent Rise In Mesenchymal Cancer Cells, and Structural Variants in Distal Neural Stem Cells

[Neuro-Oncology] Scientists used single-cell RNA-sequencing to analyze new and recurrent glioblastoma, and the nearby subventricular zone. They found four glioblastoma neural lineages were present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences.

Altered Adult Neurogenesis and Gliogenesis in Patients with Mesial Temporal Lobe Epilepsy

[Nature Neuroscience] Scientists found that a longer duration of epilepsy was associated with a sharp decline in neuronal production and persistent numbers in astrogenesis.

Oleic Acid Is an Endogenous Ligand of TLX/NR2E1 That Triggers Hippocampal Neurogenesis

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that oleic acid was critical for neural stem cell survival and demonstrated that it binds to the nuclear receptor TLX to convert it from a transcriptional repressor to a transcriptional activator of cell-cycle and neurogenesis genes.

Orthogonally Induced Differentiation of Stem Cells for the Programmatic Patterning of Vascularized Organoids and Bioprinted Tissues

[Nature Biomedical Engineering] Researchers showed that patterned organoids and bioprinted tissues with controlled composition and organization could be generated by simultaneously co-differentiating hiPSCs into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.

Asymmetric Pericentrosomal CD133 Endosomes Induce the Unequal Autophagic Activity During Cytokinesis in CD133-Positive Human Neuroblastoma Cells

[Stem Cells] Scientists suggested that the asymmetric distribution of pericentrosomal CD133 endosomes induced the symmetry breaking of autophagic activity during cytokinesis in cooperation with nuclear β-catenin.