RGCC Balances Self-Renewal and Neuronal Differentiation of Neural Stem Cells in the Developing Mammalian Neocortex

Using mouse in utero electroporation technique and in vitro human neural stem cell (NSC) differentiation models including cerebral organoids, investigators showed that regulator of cell cycle modulated NSC self-renewal and neuronal differentiation by affecting cell cycle regulation and spindle orientation.
[EMBO Journal]
RGCC balances self-renewal and neuronal differentiation of neural stem cells in the developing mammalian neocortex. (2021). EMBO Reports, n/a(n/a), e51781. https://doi.org/10.15252/embr.202051781 Cite
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Transplantable Human Motor Networks as a Neuron-Directed Strategy for Spinal Cord Injury

The authors formed encapsulated, transplantable neuronal networks of regionally matched cervical spinal motor neurons, interneurons, and oligodendrocyte progenitor cells derived through trunk-biased neuromesodermal progenitors.
[iScience]
Olmsted, Z. T., Stigliano, C., Scimemi, A., Wolfe, T., Cibelli, J., Horner, P. J., & Paluh, J. L. (2021). Transplantable human motor networks as a neuron-directed strategy for spinal cord injury. IScience, 24(8). https://doi.org/10.1016/j.isci.2021.102827 Cite
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Simultaneous Disruption of PRC2 and Enhancer Function Underlies Histone H3.3-K27M Oncogenic Activity in Human Hindbrain Neural Stem Cells

Scientists used human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landscape in a relevant developmental context.
[Nature Genetics]
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Analysis of Extracellular Vesicles as a Potential Index for Monitoring Differentiation of Neural Lineage Cells from Induced Pluripotent Stem Cells

Researchers evaluated changes in extracellular vesicles morphology, concentration, and miRNA and protein expression in culture supernatants during the differentiation of iPSCs into neural lineage cells, for application in regenerative medicine for Parkinson’s disease.
[Journal of Bioscience and Bioengineering]
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Patient-Derived iPSC-Cerebral Organoid Modeling of the 17q11.2 Microdeletion Syndrome Establishes CRLF3 as a Critical Regulator of Neurogenesis

Using patient-derived human induced pluripotent stem cell-forebrain cerebral organoids (hCOs), researchers identified both neural stem cell proliferation and neuronal maturation abnormalities in neurofibromatosis type 1-total gene deletion hCOs.
[Cell Reports]
Wegscheid, M. L., Anastasaki, C., Hartigan, K. A., Cobb, O. M., Papke, J. B., Traber, J. N., Morris, S. M., & Gutmann, D. H. (2021). Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Cell Reports, 36(1). https://doi.org/10.1016/j.celrep.2021.109315 Cite
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Fungal Brain Infection Modeled in a Human-Neurovascular-Unit-on-a-Chip with a Functional Blood-Brain Barrier

Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.
[Nature Biomedical Engineering]
Kim, J., Lee, K.-T., Lee, J. S., Shin, J., Cui, B., Yang, K., Choi, Y. S., Choi, N., Lee, S. H., Lee, J.-H., Bahn, Y.-S., & Cho, S.-W. (2021). Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier. Nature Biomedical Engineering, 1–17. https://doi.org/10.1038/s41551-021-00743-8 Cite
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Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment

Researchers report on the development of an enhanced synergistic combination therapy comprising polyacetal–curcumin nanoconjugate and neural stem cells derived from induced pluripotent stem cells + mesenchymal stem cells treatment as a treatment option for severe sub-acute traumatic spinal cord injury.
[International Journal of Molecular Sciences]
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Upregulation of Apol8 by Epothilone D Facilitates the Neuronal Relay of Transplanted NSCs in Spinal Cord Injury

Epothilone D could promote the neuronal differentiation of neural stem cells by upregulating Apol8, which might provide a promising therapeutic target for spinal cord injury repair.
[Stem Cell Research & Therapy]
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Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons

Researchers discuss the potential of prostaglandins as candidates for the development of new therapeutic drugs for motor neuron diseases.
[Cellular and Molecular Neurobiology]
Nango, H., & Kosuge, Y. (2021). Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons. Cellular and Molecular Neurobiology. https://doi.org/10.1007/s10571-021-01104-4 Cite
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Urine-Derived Induced Pluripotent/Neural Stem Cells for Modeling Neurological Diseases

Researchers describe the cellular and molecular properties of urine-derived stem cells, their differentiation potency, different reprogramming methods for the generation of iPSCs/induced neural stem cells, and their potential applications in modeling neurological diseases.
[Cell & Bioscience]
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Nuclear Isoform of FGF13 Regulates Post-Natal Neurogenesis in the Hippocampus through an Epigenomic Mechanism

Scientist found that FGF13A, the nuclear isoform of FGF13, is involved in the maintenance of neural stem cells and the suppression of neuronal differentiation during post-natal hippocampal development.
[Cell Reports]
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