Tag Archives: neural stem cells

Selective Translation of Epigenetic Modifiers Affects the Temporal Pattern and Differentiation of Neural Stem Cells

Scientists found that depletion of Fbl, an rRNA methyltransferase, reduced translation of both Ezh2 methyltransferase and Kdm6b demethylase of H3 trimethylation in Lys27 and delayed the progression of the neural stem cell state.
[Nature Communications]
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Identification and Functional Characterization of CD133+GFAP+CD117+Sca1+ Neural Stem Cells

C57BL/6 mice were used to isolate and identify CD133+GFAP+CD117+Sca1+ cells in the hippocampal dentate gyrus region of the mouse brain as a novel neural stem cell population, in terms of cell phenotype, self-renewal capacity, and differentiation capability.
[Molecular and Cellular Biochemistry]
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Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Researchers interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-derived glioblastoma (GBM) stem cells (GSCs), differentiated GBM cells, and neural stem cells to identify master regulators of GSC stemness.
[Cancer Discovery]
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Neural Stem Cells Therapy for Ischemic Stroke: Progress and Challenges

The authors provide a futher understanding of the therapeutic role of neural stem cells for ischemic stroke, and evaluate their prospects for future application in clinical patients of ischemic stroke.
[Translational Stroke Research]
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GFAP Splice Variants Fine-Tune Glioma Cell Invasion and Tumor Dynamics by Modulating Migration Persistence

The authors showed that the glial fibrillary acidic protein δ (GFAPδ) and GFAPα isoforms differentially regulated the tumor dynamics of glioma cells. Depletion of either isoform increased the migratory capacity of glioma cells.
[Scientific Reports]
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Accumulation of APP-CTF Induces Mitophagy Dysfunction in the iNSCs Model of Alzheimer’s Disease

Scientists demonstrated the effects of amyloid precursor protein-derived C-terminal fragments (APP-CTFs)-related pathology using induced neural stem cells (iNSCs) from Alzheimer’s disease patient-derived fibroblasts.
[Cell Death Discovery]
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Effect of Duty Cycles of Tumor-Treating Fields on Glioblastoma Cells and Normal Brain Organoids

The authors evaluated the effects of tumor‑treating fields with different duty cycles on glioma spheroid cells and normal brain organoids.
[International Journal of Oncology]
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Combination of Tucatinib and Neural Stem Cells Secreting Anti-HER2 Antibody Prolongs Survival of Mice with Metastatic Brain Cancer

The authors engineered the highly migratory and brain tumor tropic human neural stem cells LM008 to continuously secrete high amounts of functional, stable, full-length antibodies against human epidermal growth factor receptor 2 (HER2) without compromising the stemness of LM008 cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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Neurogenic and Cognitive Enhancing Effects of Human Dental Pulp Stem Cells and its Secretome in Animal Model of Hippocampal Neurodegeneration

Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.
[Brain Research Bulletin]
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The Potential Role of miR-1290 in Cancer Progression, Diagnosis, Prognosis, and Treatment: An oncomiR or Onco-Suppressor microRNA?

MiR-1290 was discovered for the first time in human embryonic stem cells, and under typical physiological situations, plays an essential role in neuronal differentiation and neural stem cell proliferation.
[Journal of Cellular Biochemistry]
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Sox-Positive Cell Population in the Adult Cerebellum Increases upon Tissue Degeneration

A Bergmann glia population was analyzed in the adult cerebellum of different species and showed conservation of neural stem cell-associated marker expression including Sox1, Sox2 and Sox9, in chick, primate and mouse cerebellum tissue.
[Experimental Neurology]
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