Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression

Researchers used an adapted cell preparation of isolated postnatal neural stem cells (NSCs) and live imaging to demonstrate that cerebellar progenitors maintain their neurogenic nature by displaying hallmarks of NSCs.
[Stem Cell Reports]
Paniagua-Herranz, L., Menéndez-Méndez, A., Gómez-Villafuertes, R., Olivos-Oré, L. A., Biscaia, M., Gualix, J., Pérez-Sen, R., Delicado, E. G., Artalejo, A. R., Miras-Portugal, M. T., & Ortega, F. (2020). Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.09.007 Cite
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mRNA and miRNA Expression Profile Reveals the Role of miR-31 Overexpression in Neural Stem Cell

To better understand the role of miR-31, scientists characterized the mRNA and miRNAs expression profiles in the early stage of spinal cord-derived neural stem cells after miR-31 overexpression.
[Scientific Reports]
Li, P., Gao, Y., Li, X., Tian, F., Wang, F., Wang, Y., Zhao, B., Zhang, R., & Wang, C. (2020). mRNA and miRNA expression profile reveals the role of miR-31 overexpression in neural stem cell. Scientific Reports, 10(1), 17537. https://doi.org/10.1038/s41598-020-74541-8 Cite
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Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon

Researchers showed that nascent blood vessels actively contacted dividing neural stem cells by endothelial filopodia in the ventricular zone (VZ) of the murine ventral telencephalon; this association was conserved in the human ventral VZ.
[Cell Reports]
Marco, B. D., Crouch, E. E., Shah, B., Duman, C., Paredes, M. F., Almodovar, C. R. de, Huang, E. J., & Alfonso, J. (2020). Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Reports, 33(2). https://doi.org/10.1016/j.celrep.2020.108256 Cite
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Xeno- and Transgene-Free Reprogramming of Mesenchymal Stem Cells Toward the Cells Expressing Neural Markers Using Exosome Treatments

Scientists demonstrated that treatment with exosomes derived from neural stem cells makes MSCs capable of expressing neural cell markers bypassing the generation of iPSCs.
[PLoS One]
Valerio, L. S. A., & Sugaya, K. (2020). Xeno- and transgene-free reprogramming of mesenchymal stem cells toward the cells expressing neural markers using exosome treatments. PLOS ONE, 15(10), e0240469. https://doi.org/10.1371/journal.pone.0240469 Cite
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Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalo

Scientists showed that nascent blood vessels actively contact dividing neural stem cells by endothelial filopodia in the ventricular zone (VZ) of the murine ventral telencephalon; this association was conserved in the human ventral VZ.
[Cell Reports]
Marco, B. D., Crouch, E. E., Shah, B., Duman, C., Paredes, M. F., Almodovar, C. R. de, Huang, E. J., & Alfonso, J. (2020). Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Reports, 33(2). https://doi.org/10.1016/j.celrep.2020.108256 Cite
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The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Researchers interrogated N6-methyladenosine (m6A) mRNA modifications in glioma stem cells by methyl RNA-immunoprecipitation followed by sequencing and transcriptome analysis, finding transcripts marked by m6A often upregulated compared to normal neural stem cells.
[Cancer Discovery]
Dixit, D., Prager, B. C., Gimple, R. C., Poh, H. X., Wang, Y., Wu, Q., Qiu, Z., Kidwell, R. L., Kim, L. J. Y., Xie, Q., Vitting-Seerup, K., Bhargava, S., Dong, Z., Jiang, L., Zhu, Z., Hamerlik, P., Jaffrey, S. R., Zhao, J. C., Wang, X., & Rich, J. N. (2020). The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0331 Cite
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ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis

Researchers indicated that hippocampal-neural stem cells (NSCs) senescence caused cellular exhaustion, neurogenesis reduction and cognitive impairment during aging, which can be reversed by ESC-small extracellular vesicles (sEVs).
[Molecular Therapy]
Hu, G., Xia, Y., Chen, B., Zhang, J., Gong, L., Chen, Y., Li, Q., Wang, Y., & Deng, Z. (2020). ESC-sEVs rejuvenate aging hippocampal NSCs by transferring SMADs to regulate the MYT1-Egln3-Sirt1 axis. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.09.037 Cite
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A Latent Lineage Potential in Resident Neural Stem Cells Enables Spinal Cord Repair

Researchers uncovered a latent potential in neural stem cells to replace large numbers of lost oligodendrocytes in the injured mouse spinal cord.
[Science]
Llorens-Bobadilla, E., Chell, J. M., Merre, P. L., Wu, Y., Zamboni, M., Bergenstråhle, J., Stenudd, M., Sopova, E., Lundeberg, J., Shupliakov, O., Carlén, M., & Frisén, J. (2020). A latent lineage potential in resident neural stem cells enables spinal cord repair. Science, 370(6512). https://doi.org/10.1126/science.abb8795 Cite
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Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage

Scientists systematically investigated the expression profiles of 1,436 murine RNA-binding proteins in the developing mouse brain and identified quaking as a marker of the putative glial precursor cells population.
[Stem Cell Reports]
Takeuchi, A., Takahashi, Y., Iida, K., Hosokawa, M., Irie, K., Ito, M., Brown, J. B., Ohno, K., Nakashima, K., & Hagiwara, M. (2020). Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.08.010 Cite
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Artificial Cells Drive Neural Differentiation

Scientists suggested that artificial cells were a versatile chassis for the in situ synthesis and on-demand release of chemical signals that elicited desired phenotypic changes of eukaryotic cells, including neuronal differentiation.
[Science Advances]
Toparlak, Ö. D., Zasso, J., Bridi, S., Serra, M. D., Macchi, P., Conti, L., Baudet, M.-L., & Mansy, S. S. (2020). Artificial cells drive neural differentiation. Science Advances, 6(38), eabb4920. https://doi.org/10.1126/sciadv.abb4920 Cite
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Multiplexed Analysis of Neural Cytokine Signaling by a Novel Neural Cell–Cell Interaction Microchip

The authors generated a neural cell-cell interaction microchip as an in vitro platform to simultaneously track an informed panel of cytokines and co-evaluate cell morphology and biomarker expression coupled to a sandwich ELISA platform.
[Lab on a Chip]
Abdullah, M. A. A., Amini, N., Yang, L., Paluh, J. L., & Wang, J. (2020). Multiplexed analysis of neural cytokine signaling by a novel neural cell–cell interaction microchip. Lab on a Chip. https://doi.org/10.1039/D0LC00401D Cite
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