Tag Archives: neural stem cells

A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury

Scientists showed that notch signaling-deficient astrocytes could generate new neurons after injury. Using single-cell RNA sequencing, they found that, when notch signaling was blocked, astrocytes transitioned to a neural stem cell-like state.
[Cell Stem Cell]
Zamboni, M., Llorens-Bobadilla, E., Magnusson, J. P., & Frisén, J. (2020). A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.07.006 Cite
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Activation of a Neural Stem Cell Transcriptional Program in Parenchymal Astrocytes

Researchers used single-cell RNA sequencing to characterize neurogenesis by notch-depleted striatal astrocytes in vivo.
[eLife]
Activation of a neural stem cell transcriptional program in parenchymal astrocytes | eLife. (n.d.). Retrieved August 5, 2020, from https://elifesciences.org/articles/59733 Cite
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Fabrication of Homotypic Neural Ribbons as a Multiplex Platform Optimized for Spinal Cord Delivery

Neural ribbons offer multifunctionality in vitro including co-encapsulation of the injury site ESM modifier chondroitinase ABC, tested in glial scar models, and ability of cervically-patterned spinal cord neural stem cells to differentiate within neural ribbons and project axons for integration with 3D external matrices.
[Scientific Reports]
Olmsted, Z. T., Stigliano, C., Badri, A., Zhang, F., Williams, A., Koffas, M. A. G., Xie, Y., Linhardt, R. J., Cibelli, J., Horner, P. J., & Paluh, J. L. (2020). Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery. Scientific Reports, 10(1), 12939. https://doi.org/10.1038/s41598-020-69274-7 Cite
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Intracerebral Transplantation of HLA‐Homozygous Human iPSC‐Derived Neural Precursors Ameliorates the Behavioral and Pathological Deficits in a Rodent Model of Ischemic Stroke

The authors investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
[Cell Proliferation]
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HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment

Investigators showed that hyperpolarization-activated cyclic nucleotide-gated ion channels were dynamically expressed over the cell cycle in neural stem cells.
[Molecular Cancer Research]
HCN channel activity balances quiescence and proliferation in neural stem cells and is a selective target for neuroprotection during cancer treatment. | Molecular Cancer Research. (n.d.). Retrieved July 15, 2020, from https://mcr.aacrjournals.org/content/early/2020/07/14/1541-7786.MCR-20-0292 Cite
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Nolz1 Expression Is Required in Dopaminergic Axon Guidance and Striatal Innervation

Investigators demonstrated a striatal-specific requirement of transcriptional regulator Nolz1 in establishing dopaminergic circuitry formation.
[Nature Communications]
Nolz1 expression is required in dopaminergic axon guidance and striatal innervation | Nature Communications. (n.d.). Retrieved June 24, 2020, from https://www.nature.com/articles/s41467-020-16947-6 Cite
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Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch

Researchers introduced an integration-coupled On genetic switch, iOn, which triggered gene expression upon incorporation into the host genome through transposition, thus enabling rapid and accurate identification of integration events following transfection with naked plasmids.
[Neuron]
Kumamoto, T., Maurinot, F., Barry-Martinet, R., Vaslin, C., Vandormael-Pournin, S., Le, M., Lerat, M., Niculescu, D., Cohen-Tannoudji, M., Rebsam, A., Loulier, K., Nedelec, S., Tozer, S., & Livet, J. (2020). Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch. Neuron, 0(0). https://doi.org/10.1016/j.neuron.2020.05.038 Cite
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Toxoplasma gondii Infection Impairs Radial Glia Differentiation and Its Potential to Modulate Brain Microvascular Endothelial Cell Function in the Cerebral Cortex

Conditioned medium (CM) from Radial Glia (RG) control cultures increased ZO-1 protein levels and organization on endothelial bEnd.3 cells membranes, which was impaired by CM from infected RG, accompanied by decreased trans-endothelial electrical resistance.
[Microvascular Research]
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Neural Stem Cell Delivery via Porous Collagen Scaffolds Promotes Neuronal Differentiation and Locomotion Recovery in Spinal Cord Injury

Scientists demonstrated that grafts based on porous collagen-based scaffolds, similar to biomaterials utilized clinically in induced regeneration, could deliver and protect embryonic neural stem cells at spinal cord injury (SCI) sites, leading to significant improvement in locomotion recovery in an experimental mouse SCI model.
[NPJ Regenerative Medicine]
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