The authors investigated the hypothesis that neural stem cells release and traffic functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells.
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Peruzzotti-Jametti, L., Bernstock, J. D., Willis, C. M., Manferrari, G., Rogall, R., Fernandez-Vizarra, E., Williamson, J. C., Braga, A., Bosch, A. van den, Leonardi, T., Krzak, G., Kittel, Á., Benincá, C., Vicario, N., Tan, S., Bastos, C., Bicci, I., Iraci, N., Smith, J. A., … Pluchino, S. (2021). Neural stem cells traffic functional mitochondria via extracellular vesicles. PLOS Biology, 19(4), e3001166. https://doi.org/10.1371/journal.pbio.3001166 Cite
Investigators developed a protocol enabling a derivation of MSC subpopulation with increased expression of pluripotent and neural genes.
The authors combined dynamic imaging of entire neural stem cell (NSC) populations in their in vivo niche over several weeks with pharmacological manipulations, mathematical modeling, and spatial statistics and demonstrated that NSCs use spatiotemporally resolved local feedback signals to coordinate their decision to divide in adult zebrafish brains.
[Cell Stem Cell]
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Dray, N., Mancini, L., Binshtok, U., Cheysson, F., Supatto, W., Mahou, P., Bedu, S., Ortica, S., Than-Trong, E., Krecsmarik, M., Herbert, S., Masson, J.-B., Tinevez, J.-Y., Lang, G., Beaurepaire, E., Sprinzak, D., & Bally-Cuif, L. (2021). Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.03.014 Cite
Scientists provide a simple method for the storage of neural stem cells as neurospheres at ambient temperature as an alternative method to more costly and inconvenient traditional methods of cryopreservation.
[Stem Cell Research & Therapy]
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Li, S., Zhao, H., Han, X., Ni, B., He, L., Mukama, O., de Dieu Habimana, J., Lin, Z., Huang, R., Huang, H., Tian, C., Tang, F., & Li, Z. (2021). Generation of UCiPSC-derived neurospheres for cell therapy and its application. Stem Cell Research & Therapy, 12(1), 188. https://doi.org/10.1186/s13287-021-02238-4 Cite
Scientists focus on the use of engineered cells to treat glioblastoma, with an emphasis on data from the small number of clinical trials that have been performed to date and the lessons learned from these.
[Cancer Gene Therapy]
Scientists summarize the basic characteristics, adaptive transition and implications of glioblastoma stem cells in glioblastoma therapy.
[Signal Transduction and Targeted Therapy]
Scarb1 gene expression was detected in neural stem cells (NSCs), suggesting a possible role of high density lipoproteins (HDLs) in NSC activity.
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Sulliman, N. C., Ghaddar, B., Gence, L., Patche, J., Rastegar, S., Meilhac, O., & Diotel, N. (2021). HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors. Scientific Reports, 11(1), 6439. https://doi.org/10.1038/s41598-021-85183-9 Cite
Scientists found that organoid systems display low fidelity to neuroepithelial and early radial glia cell types, but improve as neurogenesis progresses.
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Researchers describe the expression of brain abundant, membrane-attached signal protein 1 (BASP1), in neural stem cells (NSCs) in the developing and postnatal mammalian brains and human brain organoids, and demonstrated that the NSC-6 antibody may be a useful marker of these cells.
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The authors report that exon junction complexes accumulated at basal bodies of mouse neural stem cell or retinal pigment epithelial cells and declined when these cells differentiated or resumed growth.
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Kwon, O. S., Mishra, R., Safieddine, A., Coleno, E., Alasseur, Q., Faucourt, M., Barbosa, I., Bertrand, E., Spassky, N., & Le Hir, H. (2021). Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis. Nature Communications, 12(1), 1351. https://doi.org/10.1038/s41467-021-21590-w Cite
Scientists review current knowledge of how levels of neurogenesis are regulated, discuss findings regarding survival and maturation of adult-born cells and describe how newborn neurons affect brain function.
[Nature Reviews Neuroscience]