neural stem cells

[Translational Psychiatry] Spinocerebellar ataxia type 3 (SCA3)-iPSCs could be corrected by the replacement of the abnormal CAG expansions with normal repeats using CRISPR/Cas9-mediated homologous recombination strategy. Corrected SCA3-iPSCs retained pluripotent and normal karyotype, which could be differentiated into a neural stem cell and neuronal cells.

[Scientific Reports] The authors investigated the role of microglial chromodomain-helicase DNA-binding protein 8 and tuberous sclerosis complex 2 in cytokine expression, phagocytosis activity, and neuro/gliogenesis from neural stem cells in vitro.

[Stem Cell Research & Therapy] Researchers investigated the safety for clinic use and therapeutic effects of basic fibroblast growth factor-overexpressing human umbilical cord-derived MSCs in mice with completely transected spinal cord injury.

[Chembiochem] Scientists demonstrated that genomic integration of expression cassettes for a pyrrolysyl-tRNA synthetase, pyrrolysyl-tRNA and the target protein of interest enables site-specific incorporation of a non-canonical amino acid in response to amber stop codons.

[Frontiers in Cell and Developmental Biology] Research developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.

[Journal of Molecular Neuroscience] After stimulation with Zeb2/Axin2-enriched BMSC exosomes, the spatial memory and nerve function of MCAO rats showed marked recovery. The number of neurons was increased in the subventricular zone, hippocampus, and cortex area, while the expression of nerve growth factors was upregulated.