neural stem cells

[Scientific Reports] Scientists examined enteric neural stem cells integration using an adapted ex vivo organotypic culture system. Significant remodelling of the intestinal extracellular matrix and musculature occurred upon transplantation, to facilitate donor cell integration within endogenous enteric ganglia.

[Human Molecular Genetics] Scientists showed that Ogt was highly expressed in embryonic brain, and Ogt depletion reduced the proliferation of embryonic neural stem cells and migration of new born neurons.

[Calidi Biotherapeutics, Inc.] Calidi Biotherapeutics, Inc., announced that it has executed a license agreement with Northwestern University for the exclusive commercialization rights to the IND and data generated from Northwestern’s Phase 1 clinical trial treating brain tumor patients with an engineered oncolytic adenovirus delivered by neural stem cells.

[EMBO Journal] Using mouse in utero electroporation technique and in vitro human neural stem cell (NSC) differentiation models including cerebral organoids, investigators showed that regulator of cell cycle modulated NSC self-renewal and neuronal differentiation by affecting cell cycle regulation and spindle orientation.

[iScience] The authors formed encapsulated, transplantable neuronal networks of regionally matched cervical spinal motor neurons, interneurons, and oligodendrocyte progenitor cells derived through trunk-biased neuromesodermal progenitors.

[Nature Genetics] Scientists used human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landscape in a relevant developmental context.