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neuroblasts

A Comprehensive Temporal Patterning Gene Network in Drosophila Medulla Neuroblasts Revealed by Single-Cell RNA Sequencing

[Nature Communications] Researchers used single-cell RNA sequencing of Drosophila medulla neuroblasts of all ages and identified a list of previously unknown temporal transcription factors, and experimentally characterized their roles in temporal patterning and neuronal specification.

The Cell Adhesion Protein Dystroglycan Affects the Structural Remodeling of Dendritic Spines

[Scientific Reports] The authors reported that the deletion of dystroglycan (DG) in rat hippocampal cell cultures caused pronounced changes in the density and morphology of dendritic spines. They also noted a decrease in laminin, one of the major extracellular partners of DG.

Mesenchymal Type Neuroblastoma Cells Escape ALK Inhibitors

[Cancer Research] Neuroblastoma cells can adopt a lineage committed adrenergic (ADRN) or an immature mesenchymal (MES) state. Investigators found that while ADRN cells resembled normal embryonal neuroblasts, MES cells resembled immature precursor cells which also lacked ALK expression.

Lithium Treatment and Human Hippocampal Neurogenesis

[Translational Psychiatry] The authors tested the chronic effects of low and high doses of lithium on human hippocampal progenitor cells and used immunocytochemistry to investigate the effects of lithium on cell parameters implicated in neurogenesis.

Primate-Specific Stress-Induced Transcription Factor POU2F1Z Protects Human Neuronal Cells from Stress

[Scientific Reports] POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes. Increased Oct-1Z expression levels in differentiating human neuroblasts activated genes controlling stress response, neural cell differentiation, brain formation, and organogenesis.

An Implantable Human Stem Cell-Derived Tissue-Engineered Rostral Migratory Stream for Directed Neuronal Replacement

[Communications Biology] The authors demonstrated that astrocyte-like-cells could be derived from adult human gingiva mesenchymal stem cells and used for Tissue-Engineered-rostral migratory stream fabrication.

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