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neurons

The Role of Glial Cells in Multiple Sclerosis Disease Progression

[Nature Reviews Neurology] The authors provide an overview of the involvement of astrocytes and microglia at major sites of pathology in progressive multiple sclerosis.

A Combined Cell and Gene Therapy Approach for Homotopic Reconstruction of Midbrain Dopamine Pathways Using Human Pluripotent Stem Cells

[Cell Stem Cell] Researchers showed that viral delivery of GDNF to the striatum, in conjunction with homotopic transplantation of human PSC-derived midbrain dopamine (mDA) neurons, recapitulated brain-wide mDA target innervation.

Dissection of the Polygenic Architecture of Neuronal Aβ Production Using a Large Sample of Individual iPSC Lines Derived from Alzheimer’s Disease Patients

[Nature Aging] To elucidate the polygenic architecture of Alzheimer’s disease (AD) phenotypes at a cellular level, the authors established iPSCs from 102 patients with AD, differentiated them into cortical neurons and conducted a genome-wide analysis of the neuronal production of amyloid β (Aβ).

Body Weight Regulation via MT1-MMP-Mediated Cleavage of GFRAL

[Nature Metabolism] The authors showed that membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) was an endogenous negative regulator of GDNF-family receptor a-like (GFRAL) in the context of obesity.

Activation-Induced Chromatin Reorganization in Neurons Depends on HDAC1 Activity

[Cell Reports] Researchers showed that stimulation of neurons caused condensation of large chromatin domains. This phenomenon can be observed in vitro in cultured rat hippocampal neurons as well as in vivo in the amygdala and hippocampal neurons.

Raster Plots Machine Learning to Predict the Seizure Liability of Drugs and to Identify Drugs

[Scientific Reports] Researchers developed an artificial intelligence capable of predicting the seizure liability of drugs and identifying drugs using deep learning based on raster plots of neural network activity.

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