neurons

[Nature Communications] Investigators showed that Human Enterovirus A71 (HEVA71)-infected astrocytes released CXCL1 which supported viral replication in neurons by activating the CXCR2 receptor-associated ERK1/2 signaling pathway.

[npj Parkinsons Disease] The authors applied high content imaging on induced pluripotent stem cell-derived neurons from patients with familial Parkinson’s disease bearing the G209A α-synuclein mutation and launched a screening campaign on a small kinase inhibitor library.

[Nature Reviews Drug Discovery] The authors highlight general mechanisms of astrocyte regulation and their potential as therapeutic targets, including drugs that alter astrocyte metabolism, and therapies that target transporters and receptors on astrocytes.

[Frontiers in Molecular Neuroscience] Investigators review existing data on the electrophysiological properties of neurons in human cortical organoids, as well as recent advances in the complexity of cortical organoid modeling that have led to improvements in functional maturation at single neuron and neuronal network levels.

[ACS Applied Materials & interfaces] Scientists developed a CRISPR activation iPSC platform that constitutively expressed the dCas9-VPR system, which allowed robust activation of the proneural transcription factor NEUROD1 to rapidly induce neuronal differentiation within seven days.

[Advanced Science] A wireless-electrical stimulation method was proposed to direct the neural differentiation of adipose-derived MSCs (ADMSCs) based on the electromagnetic effect using a graphene film as a conductive scaffold.