Tag results:
neurons
Neural Cell News
Autism Genes Converge on Asynchronous Development of Shared Neuron Classes
[Nature] Scientists used organoid models of the human cerebral cortex to identify cell-type-specific developmental abnormalities that result from haploinsufficiency in three autism spectrum disorder risk genes—SUV420H1, ARID1B and CHD8—in multiple cell lines from different donors.
Neural Cell News
Transcriptome of Human Neuroblastoma SH-SY5Y Cells in Response to 2B Protein of Enterovirus-A71
[Scientific Reports] The authors suggested that transcriptomic profiling could provide novel information source for studying the neuropathogenesis of enterovirus-A71 infection leading to development of an effective therapeutic measure for central nervous system complications.
Neural Cell News
Selective Translation of Epigenetic Modifiers Affects the Temporal Pattern and Differentiation of Neural Stem Cells
[Nature Communications] Scientists found that depletion of Fbl, an rRNA methyltransferase, reduced translation of both Ezh2 methyltransferase and Kdm6b demethylase of H3 trimethylation in Lys27 and delayed the progression of the neural stem cell state.
Neural Cell News
Tau Interactome Maps Synaptic and Mitochondrial Processes Associated with Neurodegeneration
[Cell] Researchers showed that frontotemporal dementia mutations impaired bioenergetics and markedly diminished Tau’s interaction with mitochondria proteins, which were downregulated in Alzheimer disease brains of multiple cohorts and correlated with disease severity.
Neural Cell News
History-Dependent Dopamine Release Increases cAMP Levels in Most Basal Amygdala Glutamatergic Neurons to Control Learning
[Cell Reports] Researchers examined the dynamics of dopamine release and downstream signaling during multiple salient events occurring within tens of seconds and performed real-time tracking and manipulation of cyclic adenosine monophosphate (cAMP) in basal amygdala neurons in vitro and in vivo.
Neural Cell News
Pharmacological Brain Cytoprotection in Acute Ischaemic Stroke — Renewed Hope in the Reperfusion Era
[New England Journal of Medicine] Scientists review new types of clinical trials to evaluate whether cytoprotective drugs can slow infarct growth prior to reperfusion and/or ameliorate the consequences of reperfusion, such as haemorrhagic transformation.