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neurons

Physical Exercise Promotes Integration of Grafted Cells and Functional Recovery in an Acute Stroke Rat Model

[Stem Cell Reports] Neural progenitor cell (NPC) transplantation, combined with physical exercise, showed significant improvement in both structural and behavioral outcomes in stroke-damaged rats.

Single-Cell Transcriptomics of Human iPSC Differentiation Dynamics Reveal a Core Molecular Network of Parkinson’s Disease

[Communications Biology] Researchers investigated Parkinson’s disease (PD)'s mechanism using dopaminergic neurons differentiated from human iPSCs carrying the ILE368ASN mutation within the PINK1 gene, which is strongly associated with PD.

Stretchable Mesh Nanoelectronics for Three-Dimensional Single-Cell Chronic Electrophysiology from Developing Brain Organoids

[Advanced Materials] The authors reported a cyborg brain organoid platform, in which “tissue-like” stretchable mesh nanoelectronics are designed to match the mechanical properties of brain organoids and to be folded by the organogenetic process of progenitor or stem cells, distributing stretchable electrode arrays across the 3D organoids.

Effects of Intracellular Calcium Accumulation on Proteins Encoded by the Major Genes Underlying Amyotrophic Lateral Sclerosis

[Scientific Reports] Researchers aimed to find a relationship between the proteins coded by the most relevant genes associated with amyotrophic lateral sclerosis and intracellular Ca2+ accumulation.

JIP3 Links Lysosome Transport to Regulation of Multiple Components of the Axonal Cytoskeleton

[Communications Biology] Building on observations that mutations in the JIP3 gene result in lysosome-filled axonal swellings, scientists analyzed the impact of JIP3 depletion on the cytoskeleton of human neurons.

Organization and Dynamics of the Cortical Complexes Controlling Insulin Secretion in β-Cells

[Journal of Cell Science] Researchers showed that insulin secretion sites also contain non-neuronal proteins LL5β and KANK1, which in migrating cells organize exocytotic machinery in the vicinity of integrin-based adhesions.

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