neurons

[Nature Protocols] Scientists presented how to generate 3D spheroids resembling specific domains of the nervous system and then how to integrate them physically to allow axonal projections and synaptic assembly.

[Nature Methods] Scientists established iTracer, a lineage recorder that combined reporter barcodes with inducible CRISPR–Cas9 scarring and was compatible with single-cell and spatial transcriptomics.

[Advanced Science] A proteome map of COVID-19 skin was established and the susceptibility of human-induced pluripotent stem cell-derived skin organoids with hair follicles and nervous system was investigated, to SARS-CoV-2 infection.

[Pediatric Research] Investigators observed high KIF5C expression in neurons during the early developmental stage in mice and the human brain. Kif5c deficiency resulted in disturbed cortical neuronal migration, dendritic, and spine growth.

[Neurochemical Research] Researchers showed that epidermal growth factor (EGF) negatively regulated presynaptic maturation and synapse formation. In cortical neurons, EGF maintained axon elongation and reduced the sizes of growth cones in culture.

[Molecular Neurobiology] Using stable cell lines expressing alpha-synuclein, the authors examined the correlation between endogenous alpha-synuclein levels and the seeding propensity by exogenous alpha-synuclein preformed fibrils