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neurons

Mechanism of miR-132-3p Promoting Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson’s Disease

[eNeuro] Investigators collected evidence in both cell model and mouse models and showed the effect of miR-132-3p in enhancing the activation of microglial cells and the loss of microglia cells, which was achieved by mediating GLRX.

Inactivating Celsr2 Promotes Motor Axon Fasciculation and Regeneration in Mouse and Human

[Brain] Scientists showed that Celsr2 was highly expressed in both mouse and human spinal motoneurons. Celsr2 knockout promoted axon regeneration and fasciculation in mouse cultured spinal explants.

Large-Scale Neural Recordings Call for New Insights to Link Brain and Behavior

[Nature Neuroscience] Scientists describe emerging tools and technologies being used to probe large-scale brain activity and new approaches to characterize behavior in the context of such measurements.

Making Neurons, Made Easy: The Use of Neurogenin-2 in Neuronal Differentiation

[Stem Cell Reports] Directed neuronal differentiation of human PSCs, neural progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly reproducible differentiation of mature and functional neurons.

Neurogenic and Cognitive Enhancing Effects of Human Dental Pulp Stem Cells and its Secretome in Animal Model of Hippocampal Neurodegeneration

[Brain Research Bulletin] Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.

Single-Cell Transcriptomics Captures Features of Human Midbrain Development and Dopamine Neuron Diversity in Brain Organoids

[Nature Communications] Investigators established a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons.

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