neurons

[Cell Death & Disease] The authors showed that enterovirus 71 (EV71) engagement with intracellular receptor TLR9 elicited IL-12p40-iNOS signaling causing encephalitis in mice. They identified IL-12p40 to be the only prominent cytokine-induced at the early infection stage in the brainstem of mice subjected to a lethal dose of EV71.

[Experimental Neurology] Scientists review the different works reported in the literature that have used secretomes of Schwann cells or MSCs in the treatment of peripheral nerve injuries in experimental models.

[Open Biology] Scientists showed that the deficiency of miRNA-22a, an endothelial-enriched miRNA, caused dramatic pathfinding defects both in intersegmental vessels and primary motor neurons in zebrafish embryos.

[Nature Neuroscience] Scientists found that a longer duration of epilepsy was associated with a sharp decline in neuronal production and persistent numbers in astrogenesis.

[Science Advances] Researchers identified deubiquitinase cylindromatosis (CYLD) as a negative regulator of dopamine neuron survival, and inhibition of CYLD could potentially be beneficial in Parkinson’s disease by lowering parkin interacting substrate ZNF746 levels and promoting mitochondrial biogenesis.

[Neuroscience and Biobehavioral Reviews] The authors summarize current knowledge on the impact of astrocyte and microglia activity on behavioral outcomes, with a specific focus on brain areas relevant to higher cognitive control, reward-seeking, and circadian regulation.