The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
1254621 K57MAXHB items 1 apa default asc 1
Yang, Y., Cao, T.-T., Tian, Z.-M., Gao, H., Wen, H.-Q., Pang, M., He, W.-J., Wang, N.-X., Chen, Y.-Y., Wang, Y., Li, H., Lin, J.-W., Kang, Z., Li, M.-M., Liu, B., & Rong, L.-M. (2020). Subarachnoid transplantation of human umbilical cord mesenchymal stem cell in rodent model with subacute incomplete spinal cord injury: Preclinical safety and efficacy study. Experimental Cell Research, 112184. https://doi.org/10.1016/j.yexcr.2020.112184 Cite
The authors identified a circuit involving dopamine-receptor expressing claustral neurons projecting to frontal cortex necessary for context association of reward.
6445218 A28IN6MS items 1 apa default asc 1
Terem, A., Gonzales, B. J., Peretz-Rivlin, N., Ashwal-Fluss, R., Bleistein, N., Reus-Garcia, M. del M., Mukherjee, D., Groysman, M., & Citri, A. (2020). Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward. Current Biology, 0(0). https://doi.org/10.1016/j.cub.2020.06.064 Cite
Scientists found that zeta inhibitory peptide induced redistribution of the AMPARGluA1 in HEK293 cells and primary cortical neurons, and decreased AMPAR-mediated currents in the nucleus accumbens.
6445218 9MA2I5JI items 1 apa default asc 1
By taking advantage of a human induced pluripotent stem cell-based model, scientists aimed to gain insights on the impact of amyotrophic lateral sclerosis (ALS) mutant FUS on the motoneuron proteome.
1254621 M4QXXSV4 items 1 apa default asc 1
Garone, M. G., Alfano, V., Salvatori, B., Braccia, C., Peruzzi, G., Colantoni, A., Bozzoni, I., Armirotti, A., & Rosa, A. (2020). Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding. Scientific Reports, 10(1), 11827. https://doi.org/10.1038/s41598-020-68794-6 Cite
The authors identified distinct transcript changes in individual Piezo2-expressing mechanosensitive dorsal root ganglia neurons by combining electrophysiology with single-cell RNA sequencing.
Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
6445212 7WD6N92E items 1 apa default asc 1
Mitsuzawa, S., Zhao, C., Ikeguchi, R., Aoyama, T., Kamiya, D., Ando, M., Takeuchi, H., Akieda, S., Nakayama, K., Matsuda, S., & Ikeya, M. (2020). Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration. Scientific Reports, 10(1), 12034. https://doi.org/10.1038/s41598-020-68745-1 Cite
The Feinstein Institutes for Medical Research has been awarded a $15 million grant to study brain dysfunction tied to lupus by the National Institutes of Health. Betty Diamond, MD, director of the Feinstein’s Institute of Molecular Medicine, will use the five-year grant to investigate the role of anti-N-methyl D-aspartate receptor.
[The Feinstein Institutes for Medical Research (Business Wire, Inc.)]
The authors characterized neural precursor cells and their daughters at different stages of neurogenesis in the spiralian annelid Capitella teleta.
[BMC Evolutionary Biology]
6445218 LJGJ79VX items 1 apa default asc 1
The authors discuss recent progress in understanding how interneuron subtypes are generated in vivo, and how that progress is being applied to the generation of rodent and human cortical interneurons in vitro.
Researchers report that transamniotic bone marrow-derived mesenchymal stem cell therapy for neural tube defects during early development may achieve beneficial functional recovery.
[Cell Death & Disease]
1254621 F32VE66Y items 1 apa default asc 1
The authors examined the dose-dependent neurotoxicity of dextran-coated iron oxide nanoparticles on cultured primary neurons harvested from postnatal day 0-1 mouse brains.
6445218 QZTTYZUH items 1 apa default asc 1
To determine whether microglia also prune myelin sheaths, scientists used zebrafish to visualize and manipulate interactions between microglia, oligodendrocytes, and neurons during development.