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neurons

Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

[Stem Cell Reports] Investigators established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.

Somatic Lineage Reprogramming

[Cold Spring Harbor Perspectives in Biology] Investigators found a set of four defined factors that could reprogram fibroblasts into iPSCs, which were shown to be molecularly and functionally equivalent to blastocyst-derived ESCs, thus essentially showing that defined factors could induce authentic reprogramming without the need of oocytes.

Extracellular Matrix Remodeling through Endocytosis and Resurfacing of Tenascin-R

[Nature Communications] Investigators reported that the neuronal ECM could be remodeled frequently through mechanisms that involved endocytosis and recycling of ECM proteins.

Unlucky Punches: The Vulnerability-Stress Model for the Development of Impulse Control Disorders in Parkinson’s Disease

[npj Parkinson's Disease] The authors review current evidence for a vulnerability-stress model in which a relative reduction of dopaminergic projections to the ventral striatum and concomitant sensitization of postsynaptic neurons represent a predisposing (hypodopaminergic) vulnerability.

MiRNA-132/212 Regulates Tight Junction Stabilization in Blood–Brain Barrier after Stroke

[Cell Death Discovery] The co-culture of endothelial cells with CRTC1-deficient neurons aggravated the cell vulnerability to hypoxia, also supporting the idea that miRNA-132/212 cluster was regulated by CRTC1 and acted as a crucial role in the mitigation of ischemic damage.

STEM CELLS Translational Medicine’s Latest Young Investigator Award Winner Aims to Stop the Devastation Caused by Stroke

[Stem Cells Translational Medicine] Dr. Sara Palma-Tortosa is the 2021 recipient of the STEM CELLS Translational Medicine (SCTM) Young Investigator Award. The award honors a young researcher who served as the principal author of an article published in SCTM that, over the course of a year, is deemed to have the most impact.

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